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Poor Cognitive Function Is Associated with Obstructive Lung Diseases in Taiwanese Adults

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  • Sun-Wung Hsieh

    (Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Department of Neurology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, Taiwan
    Neuroscience Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan)

  • Da-Wei Wu

    (Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, Taiwan
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Doctoral Degree Program of Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan)

  • Chih-Wen Wang

    (Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, Taiwan
    Division of Hepatobiliary, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan)

  • Szu-Chia Chen

    (Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, Taiwan
    Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan)

  • Chih-Hsing Hung

    (Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Department of Pediatrics, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, Taiwan)

  • Chao-Hung Kuo

    (Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, Taiwan
    Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan)

Abstract

Previous studies have reported an association between the impairment of cognitive performance and lung diseases. However, whether obstructive or restrictive lung diseases have an impact on cognitive function is still inconclusive. We aimed to investigate the association between cognitive function and obstructive or restrictive lung diseases in Taiwanese adults using the Mini-Mental State Examination (MMSE). In this study, we used data from the Taiwan Biobank. Cognitive function was evaluated using the MMSE. Spirometry measurements of forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were obtained to assess lung function. Participants were classified into three groups according to lung function, namely, normal, restrictive, and obstructive lung function. In total, 683 patients enrolled, of whom 357 participants had normal lung function (52.3%), 95 had restrictive lung function (13.9%), and 231 had obstructive lung function (33.8%). Compared to the normal lung function group, the obstructive lung function group was associated with a higher percentage of cognitive impairment (MMSE < 24). In multivariable analysis, a low MMSE score was significantly associated with low FVC, low FEV1, and low FEV1/FVC. Furthermore, a low MMSE score was significantly associated with low FEV1 in the participants with FEV1/FVC < 70%, whereas MMSE was not significantly associated with FVC in the participants with FEV1/FVC ≥ 70%. Our results showed that a low MMSE score was associated with low FEV1, low FVC and low FEV1/FVC. Furthermore, a low MMSE score was associated with obstructive lung diseases but not with restrictive lung diseases.

Suggested Citation

  • Sun-Wung Hsieh & Da-Wei Wu & Chih-Wen Wang & Szu-Chia Chen & Chih-Hsing Hung & Chao-Hung Kuo, 2021. "Poor Cognitive Function Is Associated with Obstructive Lung Diseases in Taiwanese Adults," IJERPH, MDPI, vol. 18(5), pages 1-9, February.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:5:p:2344-:d:507317
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    Cited by:

    1. Jane J. Lee & Ji Hyun Kim & Dae Sub Song & Kyoungho Lee, 2022. "Effect of Short- to Long-Term Exposure to Ambient Particulate Matter on Cognitive Function in a Cohort of Middle-Aged and Older Adults: KoGES," IJERPH, MDPI, vol. 19(16), pages 1-20, August.

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