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Diversity of Oxacillinases and Sequence Types in Carbapenem-Resistant Acinetobacter baumannii from Austria

Author

Listed:
  • Andrea J. Grisold

    (D&R Institute of Hygiene, Microbiology and Environmental Medicine, Medical University Graz, Neue Stiftingtalstrasse 6, A-8010 Graz, Austria)

  • Josefa Luxner

    (D&R Institute of Hygiene, Microbiology and Environmental Medicine, Medical University Graz, Neue Stiftingtalstrasse 6, A-8010 Graz, Austria)

  • Branka Bedenić

    (Department of Microbiology, University Hospital Center Zagreb, 10000 Zagreb, Croatia)

  • Magda Diab-Elschahawi

    (Department of Infection Control and Hospital Epidemiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria)

  • Michael Berktold

    (Institute of Hygiene and Microbiology, Medical University Innsbruck, Schöpfstrasse 41, A-6020 Innsbruck, Austria)

  • Agnes Wechsler-Fördös

    (Hospital Rudolfstiftung, Juchgasse 25, 1030 Wien, Austria)

  • Gernot E. Zarfel

    (D&R Institute of Hygiene, Microbiology and Environmental Medicine, Medical University Graz, Neue Stiftingtalstrasse 6, A-8010 Graz, Austria)

Abstract

Carbapenem-resistant Acinetobacter baumannii is a significant health problem worldwide. A multicenter study on A. baumannii was performed to investigate the molecular epidemiology and genetic background of carbapenem resistance of A. baumannii isolates collected from 2014–2017 in Austria. In total, 117 non-repetitive Acinetobacter spp. assigned to A. baumannii ( n = 114) and A. pittii ( n = 3) were collected from four centers in Austria. The isolates were uniformly resistant to piperacillin/tazobactam, ceftazidime, and carbapenems, and resistance to imipenem and meropenem was 97.4% and 98.2%, respectively. The most prominent OXA-types were OXA-58-like (46.5%) and OXA-23-like (41.2%), followed by OXA-24-like (10.5%), with notable regional differences. Carbapenem-hydrolyzing class D carbapenemases (CHDLs) were the only carbapenemases found in A. baumannii isolates in Austria since no metallo-β-lactamases (MBLs) nor KPC or GES carbapenemases were detected in any of the isolates. One-third of the isolates harbored multiple CHDLs. The population structure of A. baumannii isolates from Austria was found to be very diverse, while a total of twenty-three different sequence types (STs) were identified. The most frequent was ST195 found in 15.8%, followed by ST218 and ST231 equally found in 11.4% of isolates. Two new ST types, ST2025 and ST2026, were detected. In one A. pittii isolate, bla OXA-143-like was detected for the first time in Austria.

Suggested Citation

  • Andrea J. Grisold & Josefa Luxner & Branka Bedenić & Magda Diab-Elschahawi & Michael Berktold & Agnes Wechsler-Fördös & Gernot E. Zarfel, 2021. "Diversity of Oxacillinases and Sequence Types in Carbapenem-Resistant Acinetobacter baumannii from Austria," IJERPH, MDPI, vol. 18(4), pages 1-10, February.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:4:p:2171-:d:504187
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    References listed on IDEAS

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    1. Agnieszka Litwin & Olga Fedorowicz & Wieslawa Duszynska, 2020. "Characteristics of Microbial Factors of Healthcare-Associated Infections Including Multidrug-Resistant Pathogens and Antibiotic Consumption at the University Intensive Care Unit in Poland in the Years," IJERPH, MDPI, vol. 17(19), pages 1-14, September.
    2. Clemens Kittinger & Alexander Kirschner & Michaela Lipp & Rita Baumert & Franz Mascher & Andreas H. Farnleitner & Gernot E. Zarfel, 2017. "Antibiotic Resistance of Acinetobacter spp. Isolates from the River Danube: Susceptibility Stays High," IJERPH, MDPI, vol. 15(1), pages 1-8, December.
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