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Telomere Shortening and Accelerated Aging in US Military Veterans

Author

Listed:
  • Jeffrey T. Howard

    (Department of Public Health, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA
    Consequences of Trauma Working Group, the Center for Community-Based and Applied Health Research, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA)

  • Jud C. Janak

    (Bexar Data LLC, San Antonio, TX 78210, USA)

  • Alexis R. Santos-Lozada

    (Department of Human Development and Family Studies, Pennsylvania State University, 119 Health and Human Development Building, University Park, PA 16802, USA)

  • Sarah McEvilla

    (Department of Public Health, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA)

  • Stephanie D. Ansley

    (Department of Public Health, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA
    Consequences of Trauma Working Group, the Center for Community-Based and Applied Health Research, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA)

  • Lauren E. Walker

    (David Grant USAF Medical Center, Travis Air Force Base, Fairfield, CA 94535, USA)

  • Avron Spiro

    (Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, MA 02130, USA
    Departments of Epidemiology and Psychiatry, Boston University Schools of Public Health and Medicine, Boston, MA 02118, USA)

  • Ian J. Stewart

    (Uniformed Services University of Health Sciences, Bethesda, MD 20814, USA)

Abstract

A growing body of literature on military personnel and veterans’ health suggests that prior military service may be associated with exposures that increase the risk of cardiovascular disease (CVD), which may differ by race/ethnicity. This study examined the hypothesis that differential telomere shortening, a measure of cellular aging, by race/ethnicity may explain prior findings of differential CVD risk in racial/ethnic groups with military service. Data from the first two continuous waves of the National Health and Nutrition Examination Survey (NHANES), administered from 1999–2002 were analyzed. Mean telomere length in base pairs was analyzed with multivariable adjusted linear regression with complex sample design, stratified by sex. The unadjusted mean telomere length was 225.8 base shorter for individuals with prior military service. The mean telomere length for men was 47.2 (95% CI: −92.9, −1.5; p < 0.05) base pairs shorter for men with military service after adjustment for demographic, socioeconomic, and behavioral variables, but did not differ significantly in women with and without prior military service. The interaction between military service and race/ethnicity was not significant for men or women. The results suggest that military service may contribute to accelerated aging as a result of health damaging exposures, such as combat, injury, and environmental contaminants, though other unmeasured confounders could also potentially explain the results.

Suggested Citation

  • Jeffrey T. Howard & Jud C. Janak & Alexis R. Santos-Lozada & Sarah McEvilla & Stephanie D. Ansley & Lauren E. Walker & Avron Spiro & Ian J. Stewart, 2021. "Telomere Shortening and Accelerated Aging in US Military Veterans," IJERPH, MDPI, vol. 18(4), pages 1-13, February.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:4:p:1743-:d:497552
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    References listed on IDEAS

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    1. Marta Jackowska & Mark Hamer & Livia A Carvalho & Jorge D Erusalimsky & Lee Butcher & Andrew Steptoe, 2012. "Short Sleep Duration Is Associated with Shorter Telomere Length in Healthy Men: Findings from the Whitehall II Cohort Study," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-4, October.
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