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Additive Manufacturing of Resected Oral and Oropharyngeal Tissue: A Pilot Study

Author

Listed:
  • Alexandria L. Irace

    (Department of Otorhinolaryngology–Head and Neck Surgery, HUS Helsinki University Hospital, University of Helsinki, P.O.Box 263, FI-00029 HUS Helsinki, Finland
    Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA)

  • Anne Koivuholma

    (Department of Otorhinolaryngology–Head and Neck Surgery, HUS Helsinki University Hospital, University of Helsinki, P.O.Box 263, FI-00029 HUS Helsinki, Finland
    These authors contributed equally.)

  • Eero Huotilainen

    (Department of Mechanical Engineering, Aalto University, P.O.Box 14100, FI-00076 Aalto Espoo, Finland
    These authors contributed equally.)

  • Jaana Hagström

    (Department of Pathology, HUS Helsinki University Hospital, University of Helsinki, P.O. Box 21, Haartmaninkatu 3, FI-00029 HUS Helsinki, Finland)

  • Katri Aro

    (Department of Otorhinolaryngology–Head and Neck Surgery, HUS Helsinki University Hospital, University of Helsinki, P.O.Box 263, FI-00029 HUS Helsinki, Finland)

  • Mika Salmi

    (Department of Mechanical Engineering, Aalto University, P.O.Box 14100, FI-00076 Aalto Espoo, Finland)

  • Antti Markkola

    (Department of Imaging, HUS Helsinki University Hospital, University of Helsinki, FI-00029 HUS Helsinki, Finland)

  • Heli Sistonen

    (Department of Imaging, HUS Helsinki University Hospital, University of Helsinki, FI-00029 HUS Helsinki, Finland)

  • Timo Atula

    (Department of Otorhinolaryngology–Head and Neck Surgery, HUS Helsinki University Hospital, University of Helsinki, P.O.Box 263, FI-00029 HUS Helsinki, Finland)

  • Antti A. Mäkitie

    (Department of Otorhinolaryngology–Head and Neck Surgery, HUS Helsinki University Hospital, University of Helsinki, P.O.Box 263, FI-00029 HUS Helsinki, Finland
    Department of Mechanical Engineering, Aalto University, P.O.Box 14100, FI-00076 Aalto Espoo, Finland
    Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, SE-17176 Stockholm, Sweden
    Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, FI-00014 Helsinki, Finland)

Abstract

Better visualization of tumor structure and orientation are needed in the postoperative setting. We aimed to assess the feasibility of a system in which oral and oropharyngeal tumors are resected, photographed, 3D modeled, and printed using additive manufacturing techniques. Three patients diagnosed with oral/oropharyngeal cancer were included. All patients underwent preoperative magnetic resonance imaging followed by resection. In the operating room (OR), the resected tissue block was photographed using a smartphone. Digital photos were imported into Agisoft Photoscan to produce a digital 3D model of the resected tissue. Physical models were then printed using binder jetting techniques. The aforementioned process was applied in pilot cases including carcinomas of the tongue and larynx. The number of photographs taken for each case ranged from 63 to 195. The printing time for the physical models ranged from 2 to 9 h, costs ranging from 25 to 141 EUR (28 to 161 USD). Digital photography may be used to additively manufacture models of resected oral/oropharyngeal tumors in an easy, accessible and efficient fashion. The model may be used in interdisciplinary discussion regarding postoperative care to improve understanding and collaboration, but further investigation in prospective studies is required.

Suggested Citation

  • Alexandria L. Irace & Anne Koivuholma & Eero Huotilainen & Jaana Hagström & Katri Aro & Mika Salmi & Antti Markkola & Heli Sistonen & Timo Atula & Antti A. Mäkitie, 2021. "Additive Manufacturing of Resected Oral and Oropharyngeal Tissue: A Pilot Study," IJERPH, MDPI, vol. 18(3), pages 1-12, January.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:3:p:911-:d:484601
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    References listed on IDEAS

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    1. Tamara Pawlaczyk-Kamieńska & Hanna Winiarska & Tomasz Kulczyk & Szczepan Cofta, 2020. "Dental Anomalies in Rare, Genetic Ciliopathic Disorder—A Case Report and Review of Literature," IJERPH, MDPI, vol. 17(12), pages 1-8, June.
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