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Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women

Author

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  • Joanna Suliburska

    (Department of Human Nutrition and Dietetics, Poznan University of Life Science, ul. Wojska Polskiego 31, 60-624 Poznań, Poland)

  • Agata Chmurzynska

    (Department of Human Nutrition and Dietetics, Poznan University of Life Science, ul. Wojska Polskiego 31, 60-624 Poznań, Poland)

  • Rafal Kocylowski

    (PreMediCare New Med Medical Center, ul. Drużbickiego 13, 61-693 Poznan, Poland)

  • Katarzyna Skrypnik

    (Department of Human Nutrition and Dietetics, Poznan University of Life Science, ul. Wojska Polskiego 31, 60-624 Poznań, Poland)

  • Anna Radziejewska

    (Department of Human Nutrition and Dietetics, Poznan University of Life Science, ul. Wojska Polskiego 31, 60-624 Poznań, Poland)

  • Danuta Baralkiewicz

    (Department of Trace Element Analysis by Spectroscopy Method, Faculty of Chemistry, Adam Mickiewicz University in Poznan, ul. Umultowska 89b, 61-614 Poznan, Poland)

Abstract

Although simultaneous supplementation of iron and folic acid is justified, the potential interactions between these micronutrients and other elements are poorly known. In this study, we aimed to investigate the effect of iron and folic acid supplementation on the levels of selected essential and toxic elements in the serum of micronutrient-deficient young women. A total of 40 women participated in this study and were divided into two groups: study group ( n = 23) (with iron and folate deficiency) and control group ( n = 17). The study group received iron and folic acid supplements for 3 months. Blood samples were collected at baseline and after the completion of the study period. Women completed a 3-day food intake record. We calculated the body mass index (BMI) of all the participants. Cellular morphology was analyzed in whole blood, and biochemical parameters were determined in serum. Elements were measured in serum by inductively coupled plasma mass spectrometry (ICP-MS). According to our results, in the case of the study group, the supplementation of iron and folic acid restored their levels; however, it caused a significant decrease in the level of zinc, calcium, and magnesium. In the case of the control group, at the end of the study period, there was a marked decrease in the level of iron. Interestingly, there was an increase in the level of arsenic and vanadium in both groups. In conclusion, simultaneous supplementation of iron and folic acid impairs the level of zinc, calcium, and magnesium in women of childbearing age.

Suggested Citation

  • Joanna Suliburska & Agata Chmurzynska & Rafal Kocylowski & Katarzyna Skrypnik & Anna Radziejewska & Danuta Baralkiewicz, 2021. "Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women," IJERPH, MDPI, vol. 18(3), pages 1-16, February.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:3:p:1360-:d:492013
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    References listed on IDEAS

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    1. Jianwei Gao & Jiangping Yu & Linsheng Yang, 2011. "Urinary Arsenic Metabolites of Subjects Exposed to Elevated Arsenic Present in Coal in Shaanxi Province, China," IJERPH, MDPI, vol. 8(6), pages 1-18, June.
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