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Effects of Untreated Drinking Water at Three Indigenous Yaqui Towns in Mexico: Insights from a Murine Model

Author

Listed:
  • Sofia Navarro-Espinoza

    (Department of Geology, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico)

  • Aracely Angulo-Molina

    (Department of Physics Research, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico
    Department of Biological Chemical Sciences, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico)

  • Diana Meza-Figueroa

    (Department of Geology, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico)

  • Guillermo López-Cervantes

    (Department of Medicine, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico)

  • Mercedes Meza-Montenegro

    (Department of Natural Resources, Sonora Technological Institute, 5 de Febrero 818 Sur, Obregon City 85000, Sonora, Mexico)

  • Aurora Armienta

    (Institute of Geophysics, National Autonomous University of Mexico-UNAM, Coyoacán 04510, Ciudad de Mexico, Mexico)

  • Diego Soto-Puebla

    (Department of Biological Chemical Sciences, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico)

  • Erika Silva-Campa

    (Department of Biological Chemical Sciences, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico)

  • Alexel Burgara-Estrella

    (Department of Biological Chemical Sciences, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico)

  • Osiris Álvarez-Bajo

    (Department of Biological Chemical Sciences, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico
    Consejo Nacional de Ciencia y Tecnología CONACyT, Insurgentes 1582, Benito Juárez 03940, Ciudad de Mexico, Mexico)

  • Martín Pedroza-Montero

    (Department of Biological Chemical Sciences, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico)

Abstract

Background: Reports in a northwestern Mexico state linked arsenic (As) in drinking water to DNA damage in people from indigenous communities. However, this correlation remains under discussion due to unknown variables related to nutrition, customs, and the potential presence of other metal(oid)s. Methods: To determine this association, we sampled water from three Yaqui towns (Cócorit, Vícam, and Pótam), and analyzed the metals by ICP-OES. We exposed four separate groups, with five male CD-1 mice each, to provide further insight into the potential effects of untreated drinking water. Results: The maximum concentrations of each metal(oid) in µg·L −1 were Sr(819) > Zn(135) > As(75) > Ba(57) > Mo(56) > Cu(17) > Al(14) > Mn(12) > Se(19). Histological studies revealed brain cells with angulation, satellitosis, and reactive gliosis with significant statistical correlation with Mn and As. Furthermore, the liver cells presented hepatocellular degeneration. Despite the early response, there is no occurrence of both statistical and significative changes in hematological parameters. Conclusions: The obtained results provide experimental insights to understand the potential effects of untreated water with low As and Mn contents in murine models. This fact is noteworthy because of the development of histological changes on both the brain and liver at subchronic exposure.

Suggested Citation

  • Sofia Navarro-Espinoza & Aracely Angulo-Molina & Diana Meza-Figueroa & Guillermo López-Cervantes & Mercedes Meza-Montenegro & Aurora Armienta & Diego Soto-Puebla & Erika Silva-Campa & Alexel Burgara-E, 2021. "Effects of Untreated Drinking Water at Three Indigenous Yaqui Towns in Mexico: Insights from a Murine Model," IJERPH, MDPI, vol. 18(2), pages 1-14, January.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:2:p:805-:d:482807
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    References listed on IDEAS

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    1. Soe-Minn Htway & Mya-Thanda Sein & Keiko Nohara & Tin-Tin Win-Shwe, 2019. "Effects of Developmental Arsenic Exposure on the Social Behavior and Related Gene Expression in C3H Adult Male Mice," IJERPH, MDPI, vol. 16(2), pages 1-12, January.
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