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The Predictive Role of ADRA2A rs1800544 and HTR3B rs3758987 Polymorphisms in Motion Sickness Susceptibility

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  • Xinchen Zhang

    (Institute of Environmental Systems Biology, Dalian Maritime University, Dalian 116023, China)

  • Yeqing Sun

    (Institute of Environmental Systems Biology, Dalian Maritime University, Dalian 116023, China)

Abstract

Motion sickness is a common central nervous system response, the primary sign of which is vomiting. Its susceptibility varies between individuals. To find predictive factors, we investigated the association of ADRA2A rs1800544 and HTR3B rs3758987 with motion sickness susceptibility and examined their mRNA changes during actual voyages. A total of 315 healthy college students were enrolled for SNP genotyping by the PCR-RFLP method. Blood samples were collected from another 42 subjects during two separate voyages to detect their mRNA expression changes at three time points. The frequency of the rs1800544 GG genotype in the susceptibility group was significantly higher (52.26%), and allele G increased the risk of motion sickness (OR = 1.585, 95% CI = 1.136–2.208). In the logistic regression model, the rs3758987 CC+TC genotype and rs1800544 GG genotype increased the risk of motion sickness-induced vomiting (OR = 2.105, 95% CI = 1.112–3.984; OR = 1.992, 95% CI = 1.114–3.571). The ADRA2A mRNA baseline was lower in the GG carriers and the HTR3B mRNA baseline was lower in the TC/CC carriers before sailing, then increased significantly within 24 h and then decreased after a long-term voyage. People carrying the rs1800544 GG genotype seem more susceptible to motion sickness. In combination with the incidence of vomiting during the actual-voyage experiments, our results indicate the involvement of rs1800544 and rs3758987 in motion sickness-induced vomiting.

Suggested Citation

  • Xinchen Zhang & Yeqing Sun, 2021. "The Predictive Role of ADRA2A rs1800544 and HTR3B rs3758987 Polymorphisms in Motion Sickness Susceptibility," IJERPH, MDPI, vol. 18(24), pages 1-15, December.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:24:p:13163-:d:701869
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    References listed on IDEAS

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    1. Guizhen Zhang & Vinh V. Thai & Adrian Wing‐Keung Law & Kum Fai Yuen & Hui Shan Loh & Qingji Zhou, 2020. "Quantitative Risk Assessment of Seafarers’ Nonfatal Injuries Due to Occupational Accidents Based on Bayesian Network Modeling," Risk Analysis, John Wiley & Sons, vol. 40(1), pages 8-23, January.
    2. Lutz Hein & John D. Altman & Brian K. Kobilka, 1999. "Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission," Nature, Nature, vol. 402(6758), pages 181-184, November.
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    1. Sylvia Hartmann & Summaira Yasmeen & Benjamin M. Jacobs & Spiros Denaxas & Munir Pirmohamed & Eric R. Gamazon & Mark J. Caulfield & Harry Hemingway & Maik Pietzner & Claudia Langenberg, 2023. "ADRA2A and IRX1 are putative risk genes for Raynaud’s phenomenon," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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