IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i24p13013-d698998.html
   My bibliography  Save this article

Review of the Existing Evidence for Sex-Specific Relationships between Prenatal Phthalate Exposure and Children’s Neurodevelopment

Author

Listed:
  • Agnieszka Jankowska

    (Department of Environmental and Occupational Health Hazards, Nofer Institute of Occupational Medicine (NIOM), 91-348 Lodz, Poland)

  • Linda Nazareth

    (Division of Students in English, Medical University of Lodz, 90-647 Lodz, Poland)

  • Dorota Kaleta

    (Department of Hygiene and Epidemiology, Medical University of Lodz, 90-752 Lodz, Poland)

  • Kinga Polanska

    (Department of Environmental and Occupational Health Hazards, Nofer Institute of Occupational Medicine (NIOM), 91-348 Lodz, Poland
    Department of Hygiene and Epidemiology, Medical University of Lodz, 90-752 Lodz, Poland)

Abstract

Phthalates are well-known, ubiquitous environmental contaminants influencing children’s health and their neurodevelopment. However, results of the previously conducted studies are not entirely conclusive. The aim of this review is to present the current state of knowledge with respect to the association between the prenatal phthalate exposure and sex-specific child neurodevelopmental outcomes. A systematic search of the literature was carried out to identify the studies that analyse the sex-specific association between prenatal exposure to phthalates and cognitive, psychomotor outcomes and behavioural and emotional problems. The search was conducted in May 2021, and it was limited to the papers published in English between January 2015 and April 2021. The following databases were used: PubMed, Scopus and Elsevier. The selection process was carried out by two independent authors according to the inclusion criteria. Of a total of 7542 records, 17 epidemiological studies met the inclusion criteria with regards to phthalate exposure and sex-specific differences in child neurobehavioural development. The review shows no clear pattern of association between maternal exposure to phthalates during pregnancy and offspring neurodevelopment. No clearly pronounced sex specific effects, except for BBzP exposure and decreased motor ablates among girls, have been indicated. Inconsistences in the results, as well as unsolved issues related to the interpretation of the results in the context of the exposure level, outcomes, confounders, and biological plausibility highlight the necessity for further research in the field.

Suggested Citation

  • Agnieszka Jankowska & Linda Nazareth & Dorota Kaleta & Kinga Polanska, 2021. "Review of the Existing Evidence for Sex-Specific Relationships between Prenatal Phthalate Exposure and Children’s Neurodevelopment," IJERPH, MDPI, vol. 18(24), pages 1-18, December.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:24:p:13013-:d:698998
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/24/13013/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/24/13013/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Małgorzata Znyk & Joanna Jurewicz & Dorota Kaleta, 2021. "Exposure to Heated Tobacco Products and Adverse Health Effects, a Systematic Review," IJERPH, MDPI, vol. 18(12), pages 1-18, June.
    2. Ruihua Dong & Shanzhen Zhao & Han Zhang & Jingsi Chen & Meiru Zhang & Min Wang & Min Wu & Shuguang Li & Bo Chen, 2017. "Sex Differences in the Association of Urinary Concentrations of Phthalates Metabolites with Self-Reported Diabetes and Cardiovascular Diseases in Shanghai Adults," IJERPH, MDPI, vol. 14(6), pages 1-15, June.
    3. Machiko Minatoya & Reiko Kishi, 2021. "A Review of Recent Studies on Bisphenol A and Phthalate Exposures and Child Neurodevelopment," IJERPH, MDPI, vol. 18(7), pages 1-21, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yoshihiko Hosokawa & Masayoshi Zaitsu & Sumiyo Okawa & Naho Morisaki & Ai Hori & Yukiko Nishihama & Shoji F. Nakayama & Takeo Fujiwara & Hiromi Hamada & Toyomi Satoh & Takahiro Tabuchi, 2022. "Association between Heated Tobacco Product Use during Pregnancy and Fetal Growth in Japan: A Nationwide Web-Based Survey," IJERPH, MDPI, vol. 19(18), pages 1-9, September.
    2. Lindsey S. Sparrock & Lilianna Phan & Julia Chen-Sankey & Kiana Hacker & Aniruddh Ajith & Bambi Jewett & Kelvin Choi, 2023. "Heated Tobacco Products: Awareness, Beliefs, Use and Susceptibility among US Adult Current Tobacco Users, 2021," IJERPH, MDPI, vol. 20(3), pages 1-11, January.
    3. Elisabet Söderström & Torbjörn K. Nilsson & Jörn Schneede & Per-Magne Ueland & Øivind Midttun & Björn Gylling & Ingegerd Johansson & Johan Hultdin, 2021. "Plasma Cotinine Is Positively Associated with Homocysteine in Smokers but Not in Users of Smokeless Tobacco," IJERPH, MDPI, vol. 18(21), pages 1-9, October.
    4. David T. Levy & Christopher J. Cadham & Yameng Li & Zhe Yuan & Alex C. Liber & Hayoung Oh & Nargiz Travis & Mona Issabakhsh & David T. Sweanor & Luz Maria Sánchez-Romero & Rafael Meza & K. Michael Cum, 2022. "A Decision-Theoretic Public Health Framework for Heated Tobacco and Nicotine Vaping Products," IJERPH, MDPI, vol. 19(20), pages 1-17, October.
    5. Hong Gwan Seo & Steve S. Xu & Grace Li & Shannon Gravely & Anne C. K. Quah & Sungkyu Lee & Sujin Lim & Sung-il Cho & Yeol Kim & Eon Sook Lee & Yoon-Jung Choi & Connor R. Miller & Maciej L. Goniewicz &, 2023. "Reasons for Initiation and Regular Use of Heated Tobacco Products among Current and Former Smokers in South Korea: Findings from the 2020 ITC Korea Survey," IJERPH, MDPI, vol. 20(6), pages 1-12, March.
    6. Hagai Levine & Zongshuan Duan & Yael Bar-Zeev & Lorien C. Abroms & Amal Khayat & Sararat Tosakoon & Katelyn F. Romm & Yan Wang & Carla J. Berg, 2023. "IQOS Use and Interest by Sociodemographic and Tobacco Behavior Characteristics among Adults in the US and Israel," IJERPH, MDPI, vol. 20(4), pages 1-14, February.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:24:p:13013-:d:698998. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.