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Drug–Drug Interactions in Vestibular Diseases, Clinical Problems, and Medico-Legal Implications

Author

Listed:
  • Giulio Di Mizio

    (Department of Law, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy
    Marcianò and Di Mizio share the authorship.)

  • Gianmarco Marcianò

    (Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, 88100 Catanzaro, Italy
    Marcianò and Di Mizio share the authorship.)

  • Caterina Palleria

    (Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, 88100 Catanzaro, Italy)

  • Lucia Muraca

    (Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, 88100 Catanzaro, Italy
    Department of Primary Care, ASP 7, 88100 Catanzaro, Italy)

  • Vincenzo Rania

    (Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, 88100 Catanzaro, Italy)

  • Roberta Roberti

    (Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, 88100 Catanzaro, Italy)

  • Giuseppe Spaziano

    (Department of Experimental Medicine L. Donatelli, Section of Pharmacology, School of Medicine, University of Campania Luigi Vanvitelli, 80123 Naples, Italy)

  • Amalia Piscopo

    (Department of Law, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy)

  • Valeria Ciconte

    (Department of Law, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy
    Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, 88100 Catanzaro, Italy)

  • Nunzio Di Nunno

    (Department of History, Society and Studies on Humanity, University of Salento, 83100 Lecce, Italy)

  • Massimiliano Esposito

    (Department of Medical, Surgical Sciences and Advanced Technologies “G. F. Ingrassia”, University of Catania, 95121 Catania, Italy)

  • Pasquale Viola

    (Unit of Audiology, Department of Experimental and Clinical Medicine, Regional Centre of Cochlear Implants and ENT Diseases, Magna Graecia University, 88100 Catanzaro, Italy)

  • Davide Pisani

    (Unit of Audiology, Department of Experimental and Clinical Medicine, Regional Centre of Cochlear Implants and ENT Diseases, Magna Graecia University, 88100 Catanzaro, Italy)

  • Giovambattista De Sarro

    (Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, 88100 Catanzaro, Italy
    Research Center FAS@UMG, Department of Health Science, University of Catanzaro, 88100 Catanzaro, Italy)

  • Milena Raffi

    (Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy)

  • Alessandro Piras

    (Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy)

  • Giuseppe Chiarella

    (Unit of Audiology, Department of Experimental and Clinical Medicine, Regional Centre of Cochlear Implants and ENT Diseases, Magna Graecia University, 88100 Catanzaro, Italy
    Gallelli and Chiarella share the authorship.)

  • Luca Gallelli

    (Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, 88100 Catanzaro, Italy
    Research Center FAS@UMG, Department of Health Science, University of Catanzaro, 88100 Catanzaro, Italy
    Medifarmagen SRL, University of Catanzaro, 88100 Catanzaro, Italy
    Gallelli and Chiarella share the authorship.)

Abstract

Peripheral vestibular disease can be treated with several approaches (e.g., maneuvers, surgery, or medical approach). Comorbidity is common in elderly patients, so polytherapy is used, but it can generate the development of drug–drug interactions (DDIs) that play a role in both adverse drug reactions and reduced adherence. For this reason, they need a complex kind of approach, considering all their individual characteristics. Physicians must be able to prescribe and deprescribe drugs based on a solid knowledge of pharmacokinetics, pharmacodynamics, and clinical indications. Moreover, full information is required to reach a real therapeutic alliance, to improve the safety of care and reduce possible malpractice claims related to drug–drug interactions. In this review, using PubMed, Embase, and Cochrane library, we searched articles published until 30 August 2021, and described both pharmacokinetic and pharmacodynamic DDIs in patients with vestibular disorders, focusing the interest on their clinical implications and on risk management strategies.

Suggested Citation

  • Giulio Di Mizio & Gianmarco Marcianò & Caterina Palleria & Lucia Muraca & Vincenzo Rania & Roberta Roberti & Giuseppe Spaziano & Amalia Piscopo & Valeria Ciconte & Nunzio Di Nunno & Massimiliano Espos, 2021. "Drug–Drug Interactions in Vestibular Diseases, Clinical Problems, and Medico-Legal Implications," IJERPH, MDPI, vol. 18(24), pages 1-42, December.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:24:p:12936-:d:697614
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    References listed on IDEAS

    as
    1. Fulvio Plescia & Pietro Salvago & Francesco Dispenza & Giuseppe Messina & Emanuele Cannizzaro & Francesco Martines, 2021. "Efficacy and Pharmacological Appropriateness of Cinnarizine and Dimenhydrinate in the Treatment of Vertigo and Related Symptoms," IJERPH, MDPI, vol. 18(9), pages 1-14, April.
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