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The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?

Author

Listed:
  • Juan Pablo López-Cervantes

    (Center for International Health, Department of Global Public Health and Primary Care, University of Bergen, 5020 Bergen, Norway
    Department of Occupational Medicine, Haukeland University Hospital, 5021 Bergen, Norway)

  • Marianne Lønnebotn

    (Center for International Health, Department of Global Public Health and Primary Care, University of Bergen, 5020 Bergen, Norway
    Department of Occupational Medicine, Haukeland University Hospital, 5021 Bergen, Norway)

  • Nils Oskar Jogi

    (Department of Occupational Medicine, Haukeland University Hospital, 5021 Bergen, Norway
    Department of Clinical Science, University of Bergen, 5021 Bergen, Norway)

  • Lucia Calciano

    (Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy)

  • Ingrid Nordeide Kuiper

    (Department of Pediatrics, Haukeland University Hospital, 5021 Bergen, Norway)

  • Matthew G. Darby

    (Institute of Infectious Disease and Molecular Medicine and Division of Immunology, University of Cape Town, Cape Town 7925, South Africa)

  • Shyamali C. Dharmage

    (School of Population and Global Health, University of Melbourne, Melbourne, VIC 3010, Australia)

  • Francisco Gómez-Real

    (Department of Clinical Science, University of Bergen, 5021 Bergen, Norway
    Department of Obstetrics and Gynecology, Haukeland University Hospital, 5053 Bergen, Norway)

  • Barbara Hammer

    (Department of Pulmonology, Medical University of Vienna, 1090 Vienna, Austria)

  • Randi Jacobsen Bertelsen

    (Department of Clinical Science, University of Bergen, 5021 Bergen, Norway)

  • Ane Johannessen

    (Center for International Health, Department of Global Public Health and Primary Care, University of Bergen, 5020 Bergen, Norway)

  • Anne Mette Lund Würtz

    (Danish Ramazzini Centre, Department of Public Health—Work, Environment and Health, Aarhus University, 8000 Aarhus, Denmark)

  • Toril Mørkve Knudsen

    (Department of Occupational Medicine, Haukeland University Hospital, 5021 Bergen, Norway
    Department of Clinical Science, University of Bergen, 5021 Bergen, Norway)

  • Jennifer Koplin

    (School of Population and Global Health, University of Melbourne, Melbourne, VIC 3010, Australia
    Murdoch Children’s Research Institute, Melbourne, VIC 3052, Australia)

  • Kathrine Pape

    (Danish Ramazzini Centre, Department of Public Health—Work, Environment and Health, Aarhus University, 8000 Aarhus, Denmark)

  • Svein Magne Skulstad

    (Department of Occupational Medicine, Haukeland University Hospital, 5021 Bergen, Norway)

  • Signe Timm

    (Department of Regional Health Research, University of Southern Denmark, 5230 Odense, Denmark
    Research Unit, Kolding Hospital, University Hospital of Southern Denmark, 6000 Kolding, Denmark)

  • Gro Tjalvin

    (Center for International Health, Department of Global Public Health and Primary Care, University of Bergen, 5020 Bergen, Norway
    Department of Occupational Medicine, Haukeland University Hospital, 5021 Bergen, Norway)

  • Susanne Krauss-Etschmann

    (Research Center Borstel, Leibniz Lung Center, 23845 Borstel, Germany)

  • Simone Accordini

    (Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy)

  • Vivi Schlünssen

    (Danish Ramazzini Centre, Department of Public Health—Work, Environment and Health, Aarhus University, 8000 Aarhus, Denmark
    National Research Centre for the Working Environment, 2100 Copenhagen, Denmark)

  • Jorunn Kirkeleit

    (Center for International Health, Department of Global Public Health and Primary Care, University of Bergen, 5020 Bergen, Norway
    Department of Occupational Medicine, Haukeland University Hospital, 5021 Bergen, Norway
    These authors contributed equally as last authors.)

  • Cecilie Svanes

    (Center for International Health, Department of Global Public Health and Primary Care, University of Bergen, 5020 Bergen, Norway
    Department of Occupational Medicine, Haukeland University Hospital, 5021 Bergen, Norway
    These authors contributed equally as last authors.)

Abstract

Emerging research suggests environmental exposures before conception may adversely affect allergies and lung diseases in future generations. Most studies are limited as they have focused on single exposures, not considering that these diseases have a multifactorial origin in which environmental and lifestyle factors are likely to interact. Traditional exposure assessment methods fail to capture the interactions among environmental exposures and their impact on fundamental biological processes, as well as individual and temporal factors. A valid estimation of exposure preconception is difficult since the human reproductive cycle spans decades and the access to germ cells is limited. The exposome is defined as the cumulative measure of external exposures on an organism (external exposome), and the associated biological responses (endogenous exposome) throughout the lifespan, from conception and onwards. An exposome approach implies a targeted or agnostic analysis of the concurrent and temporal multiple exposures, and may, together with recent technological advances, improve the assessment of the environmental contributors to health and disease. This review describes the current knowledge on preconception environmental exposures as related to respiratory health outcomes in offspring. We discuss the usefulness and feasibility of using an exposome approach in this research, advocating for the preconception exposure window to become included in the exposome concept.

Suggested Citation

  • Juan Pablo López-Cervantes & Marianne Lønnebotn & Nils Oskar Jogi & Lucia Calciano & Ingrid Nordeide Kuiper & Matthew G. Darby & Shyamali C. Dharmage & Francisco Gómez-Real & Barbara Hammer & Randi Ja, 2021. "The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?," IJERPH, MDPI, vol. 18(23), pages 1-20, December.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:23:p:12684-:d:692991
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    References listed on IDEAS

    as
    1. Miranda Loh & Dimosthenis Sarigiannis & Alberto Gotti & Spyros Karakitsios & Anjoeka Pronk & Eelco Kuijpers & Isabella Annesi-Maesano & Nour Baiz & Joana Madureira & Eduardo Oliveira Fernandes & Micha, 2017. "How Sensors Might Help Define the External Exposome," IJERPH, MDPI, vol. 14(4), pages 1-14, April.
    2. Ingrid Nordeide Kuiper & Iana Markevych & Simone Accordini & Randi J. Bertelsen & Lennart Bråbäck & Jesper Heile Christensen & Bertil Forsberg & Thomas Halvorsen & Joachim Heinrich & Ole Hertel & Gera, 2020. "Associations of Preconception Exposure to Air Pollution and Greenness with Offspring Asthma and Hay Fever," IJERPH, MDPI, vol. 17(16), pages 1-14, August.
    3. Alicia Guillien & Solène Cadiou & Rémy Slama & Valérie Siroux, 2021. "The Exposome Approach to Decipher the Role of Multiple Environmental and Lifestyle Determinants in Asthma," IJERPH, MDPI, vol. 18(3), pages 1-14, January.
    Full references (including those not matched with items on IDEAS)

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