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Current Thoughts of Notch’s Role in Myoblast Regulation and Muscle-Associated Disease

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  • Jeffrey C. Gerrard

    (Department of Applied Physiology, Health and Clinical Sciences, University of North Carolina-Charlotte, Charlotte, NC 28223, USA)

  • Jamison P. Hay

    (Department of Applied Physiology, Health and Clinical Sciences, University of North Carolina-Charlotte, Charlotte, NC 28223, USA)

  • Ryan N. Adams

    (Department of Applied Physiology, Health and Clinical Sciences, University of North Carolina-Charlotte, Charlotte, NC 28223, USA)

  • James C. Williams

    (Department of Applied Physiology, Health and Clinical Sciences, University of North Carolina-Charlotte, Charlotte, NC 28223, USA)

  • Joshua R. Huot

    (Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA)

  • Kaitlin M. Weathers

    (Department of Applied Physiology, Health and Clinical Sciences, University of North Carolina-Charlotte, Charlotte, NC 28223, USA)

  • Joseph S. Marino

    (Department of Applied Physiology, Health and Clinical Sciences, University of North Carolina-Charlotte, Charlotte, NC 28223, USA)

  • Susan T. Arthur

    (Department of Applied Physiology, Health and Clinical Sciences, University of North Carolina-Charlotte, Charlotte, NC 28223, USA)

Abstract

The evolutionarily conserved signaling pathway Notch is unequivocally essential for embryogenesis. Notch’s contribution to the muscle repair process in adult tissue is complex and obscure but necessary. Notch integrates with other signals in a functional antagonist manner to direct myoblast activity and ultimately complete muscle repair. There is profound recent evidence describing plausible mechanisms of Notch in muscle repair. However, the story is not definitive as evidence is slowly emerging that negates Notch’s importance in myoblast proliferation. The purpose of this review article is to examine the prominent evidence and associated mechanisms of Notch’s contribution to the myogenic repair phases. In addition, we discuss the emerging roles of Notch in diseases associated with muscle atrophy. Understanding the mechanisms of Notch’s orchestration is useful for developing therapeutic targets for disease.

Suggested Citation

  • Jeffrey C. Gerrard & Jamison P. Hay & Ryan N. Adams & James C. Williams & Joshua R. Huot & Kaitlin M. Weathers & Joseph S. Marino & Susan T. Arthur, 2021. "Current Thoughts of Notch’s Role in Myoblast Regulation and Muscle-Associated Disease," IJERPH, MDPI, vol. 18(23), pages 1-20, November.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:23:p:12558-:d:690390
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    References listed on IDEAS

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    1. Joe V. Chakkalakal & Kieran M. Jones & M. Albert Basson & Andrew S. Brack, 2012. "The aged niche disrupts muscle stem cell quiescence," Nature, Nature, vol. 490(7420), pages 355-360, October.
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