IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i22p12159-d683097.html
   My bibliography  Save this article

Associations between Brain Reserve Proxies and Clinical Progression in Alzheimer’s Disease Dementia

Author

Listed:
  • Hyung-Jun Yoon

    (Department of Neuropsychiatry, College of Medicine, Chosun University/Chosun University Hospital, Gwangju 61452, Korea)

  • Seung-Gon Kim

    (Department of Neuropsychiatry, College of Medicine, Chosun University/Chosun University Hospital, Gwangju 61452, Korea)

  • Sang Hoon Kim

    (Department of Neuropsychiatry, College of Medicine, Chosun University/Chosun University Hospital, Gwangju 61452, Korea)

  • Jong Inn Woo

    (Department of Neuropsychiatry, College of Medicine, Seoul National University Hospital, Seoul 03080, Korea)

  • Eun Hyun Seo

    (Premedical Science, College of Medicine, Chosun University, Gwangju 61452, Korea)

  • For the Alzheimer’s Disease Neuroimaing Initiative

    (For The Alzheimer’s Disease Neuroimaing Initiative is provided in the Acknowledgements.)

Abstract

The purpose of this study was to investigate whether brain and cognitive reserves were associated with the clinical progression of AD dementia. We included participants with AD dementia from the Alzheimer’s Disease Neuroimaging Initiative, provided they were followed up at least once, and candidate proxies for cognitive (education for early-life reserve and Adult Reading Test for late-life reserve) or brain reserve (intracranial volume [ICV] for early-life reserve and the composite value of [ 18 F] fluorodeoxyglucose positron emission tomography regions of interest (FDG-ROIs) for late-life reserve) were available. The final analysis included 120 participants. Cox proportional hazards model revealed that FDG-ROIs were the only significant predictor of clinical progression. Subgroup analysis revealed a significant association between FDG-ROIs and clinical progression only in the larger ICV group (HR = 0.388, p = 0.028, 95% CI 0.167–0.902). Our preliminary findings suggest that relatively preserved cerebral glucose metabolism might delay further clinical progression in AD dementia, particularly in the greater ICV group. In addition to ICV, cerebral glucose metabolism could play an important role as a late-life brain reserve in the process of neurodegeneration. Distinguishing between early- and late-life reserves, and considering both proxies simultaneously, would provide a wider range of factors associated with the prognosis of AD dementia.

Suggested Citation

  • Hyung-Jun Yoon & Seung-Gon Kim & Sang Hoon Kim & Jong Inn Woo & Eun Hyun Seo & For the Alzheimer’s Disease Neuroimaing Initiative, 2021. "Associations between Brain Reserve Proxies and Clinical Progression in Alzheimer’s Disease Dementia," IJERPH, MDPI, vol. 18(22), pages 1-11, November.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:22:p:12159-:d:683097
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/22/12159/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/22/12159/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Hui-Xin Wang & Stuart W S MacDonald & Serhiy Dekhtyar & Laura Fratiglioni, 2017. "Association of lifelong exposure to cognitive reserve-enhancing factors with dementia risk: A community-based cohort study," PLOS Medicine, Public Library of Science, vol. 14(3), pages 1-17, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Moorman, Sara M. & Carr, Kyle & Greenfield, Emily A., 2018. "Childhood socioeconomic status and genetic risk for poorer cognition in later life," Social Science & Medicine, Elsevier, vol. 212(C), pages 219-226.
    2. Sean A. P. Clouston & Graciela Muniz Terrera & Joseph Lee Rodgers & Patrick O'Keefe & Frank D. Mann & Nathan A. Lewis & Linda Wänström & Jeffrey Kaye & Scott M. Hofer, 2021. "Cohort and Period Effects as Explanations for Declining Dementia Trends and Cognitive Aging," Population and Development Review, The Population Council, Inc., vol. 47(3), pages 611-637, September.
    3. Marie Astrid Garrido & Lorenz Mark & Manuel Parra & Dennis Nowak & Katja Radon, 2021. "Executive Function among Chilean Shellfish Divers: A Cross-Sectional Study Considering Working and Health Conditions in Artisanal Fishing," IJERPH, MDPI, vol. 18(11), pages 1-13, May.
    4. Hye-Jin Kim & Jin-Young Min & Kyoung-Bok Min, 2020. "The Association between Longest-Held Lifetime Occupation and Late-Life Cognitive Impairment: Korean Longitudinal Study of Aging (2006–2016)," IJERPH, MDPI, vol. 17(17), pages 1-14, August.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:22:p:12159-:d:683097. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.