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Down Syndrome in Brazil: Occurrence and Associated Factors

Author

Listed:
  • Mariana Rabello Laignier

    (Nursing Department at the Health Sciences Center, Universidade Federal do Espírito Santo, Vitória 29075-910, Brazil)

  • Luís Carlos Lopes-Júnior

    (Nursing Department at the Health Sciences Center, Universidade Federal do Espírito Santo, Vitória 29075-910, Brazil)

  • Raquel Esperidon Santana

    (Associação de Pais, Amigos e Pessoas com Síndrome de Down do Espírito Santo, Vitória 29075-910, Brazil)

  • Franciéle Marabotti Costa Leite

    (Nursing Department at the Health Sciences Center, Universidade Federal do Espírito Santo, Vitória 29075-910, Brazil)

  • Carolina Laura Brancato

    (Associação de Pais, Amigos e Pessoas com Síndrome de Down do Espírito Santo, Vitória 29075-910, Brazil)

Abstract

Background: Down syndrome is the most frequent genetic cause of intellectual disability, with an estimated birth prevalence of 14 per 10,000 live births. In Brazil, statistical data on the occurrence of babies born with Down syndrome remain unclear. We aimed to estimate the occurrence of Down syndrome between 2012 and 2018, and to observe its association with maternal, gestational, paternal characteristics, and newborn vitality. Methods: A retrospective study was carried out using secondary data included in the Certificate of Live Birth in a state located in the southeastern region of Brazil. Data analysis was performed in the software Stata 14.1. Pearson’s chi-square test for bivariate analysis, and logistic regression for multivariate analysis were performed, with a 95% confidence interval (CI) and a significance of 5%. Results: We observed that 157 cases of Down syndrome were reported among 386,571 live births, representing an incidence of 4 in 10,000 live births. Down syndrome was associated with maternal age ≥ 35 years, paternal age ≥ 30 years, the performance of six or more prenatal consultations, prematurity, and low birth weight ( p < 0.05). Conclusions: Women aged 35 and over were more likely to have children born with Down syndrome. In addition, there is an association of Down syndrome with premature birth, low birth weight, and the number of prenatal consultations (≥6).

Suggested Citation

  • Mariana Rabello Laignier & Luís Carlos Lopes-Júnior & Raquel Esperidon Santana & Franciéle Marabotti Costa Leite & Carolina Laura Brancato, 2021. "Down Syndrome in Brazil: Occurrence and Associated Factors," IJERPH, MDPI, vol. 18(22), pages 1-11, November.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:22:p:11954-:d:678866
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    References listed on IDEAS

    as
    1. Luís Carlos Lopes‐Júnior & Paulo Marcondes Carvalho Júnior & Victor Evangelista de Faria Ferraz & Lucila Castanheira Nascimento & Marcia Van Riper & Milena Flória‐Santos, 2017. "Genetic education, knowledge and experiences between nurses and physicians in primary care in Brazil: A cross‐sectional study," Nursing & Health Sciences, John Wiley & Sons, vol. 19(1), pages 66-74, March.
    2. Elisa Fucà & Floriana Costanzo & Laura Celestini & Alessandra Mandarino & Stefano Vicari, 2021. "Characterization of Sleep Disturbances in Children and Adolescents with Down Syndrome and Their Relation with Cognitive and Behavioral Features," IJERPH, MDPI, vol. 18(9), pages 1-14, May.
    3. Fatma Haddad & Jenny Bourke & Kingsley Wong & Helen Leonard, 2018. "An investigation of the determinants of quality of life in adolescents and young adults with Down syndrome," PLOS ONE, Public Library of Science, vol. 13(6), pages 1-19, June.
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    Cited by:

    1. Luís Carlos Lopes-Júnior & Victor Evangelista Faria Ferraz & Regina Aparecida Garcia Lima & Sara Isabel Pimentel Carvalho Schuab & Raphael Manhães Pessanha & Geisa Santos Luz & Mariana Rabello Laignie, 2022. "Health Policies for Rare Disease Patients: A Scoping Review," IJERPH, MDPI, vol. 19(22), pages 1-19, November.
    2. Luís Carlos Lopes-Júnior & Larissa Soares Dell’Antonio & Raphael Manhaes Pessanha & Cristiano Soares Dell’Antonio & Michelaine Isabel da Silva & Thayna Mamedi de Souza & Jonathan Grassi, 2022. "Completeness and Consistency of Epidemiological Variables from Hospital-Based Cancer Registries in a Brazilian State," IJERPH, MDPI, vol. 19(19), pages 1-16, September.

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