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Diagnostic Accuracy of SARS-CoV-2 Antigen Tests for Community Transmission Screening: A Systematic Review and Meta-Analysis

Author

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  • Cheng-Chieh Chen

    (Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
    Department of Pathology and Laboratory Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 11101, Taiwan
    These authors contributed equally to this work.)

  • Shou-Cheng Lu

    (Department of Laboratory Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan
    These authors contributed equally to this work.)

  • Chyi-Huey Bai

    (Department of Public Health, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
    These authors contributed equally to this work.)

  • Pei-Yu Wang

    (Department of Laboratory Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan)

  • Kang-Yun Lee

    (Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan
    Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan)

  • Yuan-Hung Wang

    (Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
    Department of Medical Research, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan)

Abstract

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) caused the global pandemic of coronavirus disease 2019 (COVID-19). Rapid identification and isolation of infectious patients are critical methods to block COVID-19 transmission. Antigen tests can contribute to prompt identification of infectious individuals. This meta-analysis aims to evaluate the diagnostic accuracy of antigen tests for SARS-CoV-2. We conducted a literature search in PubMed, Embase, the Cochrane Library, and Biomed Central databases. Studies evaluating the diagnostic accuracy of antigen tests for SARS-CoV-2 in community participants were included. Only English-language articles were reviewed. We included eligible studies that provided available data to construct a 2 × 2 table on a per-patient basis. Overall sensitivity and specificity for antigen tests were generated using a bivariate random-effects model. Eighteen studies with 34,865 participants were retrieved. The meta-analysis for SARS-CoV-2 antigen tests generated a pooled sensitivity of 0.82 and a pooled specificity of 1.00. A subgroup analysis of ten studies that reported outcomes for 5629 symptomatic participants generated a pooled sensitivity of 0.87 and a pooled specificity of 1.00. Antigen tests might have higher sensitivity in detecting SARS-CoV-2 in symptomatic patients in the community and may be an effective tool to identify patients to be quarantined to prevent further SARS-CoV-2 transmission.

Suggested Citation

  • Cheng-Chieh Chen & Shou-Cheng Lu & Chyi-Huey Bai & Pei-Yu Wang & Kang-Yun Lee & Yuan-Hung Wang, 2021. "Diagnostic Accuracy of SARS-CoV-2 Antigen Tests for Community Transmission Screening: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 18(21), pages 1-14, October.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:21:p:11451-:d:669073
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    Cited by:

    1. Jing Qi & Jia Neng Tan & Soh Heng Hui & Neoh Choo Lim & Titus Lau & Sabrina Haroon, 2022. "The Implementation and Role of Antigen Rapid Test for COVID-19 in Hemodialysis Units," IJERPH, MDPI, vol. 19(22), pages 1-10, November.
    2. Dawid Szurgacz & Sergey Zhironkin & Jiří Pokorný & A. J. S. (Sam) Spearing & Stefan Vöth & Michal Cehlár & Izabela Kowalewska, 2021. "Development of an Active Training Method for Belt Conveyor," IJERPH, MDPI, vol. 19(1), pages 1-12, December.

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