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Association of Pesticides and Kidney Function among Adults in the US Population 2001–2010

Author

Listed:
  • En-Tzu Wan

    (School of Public Health, The University of Queensland, Brisbane 4006, Australia
    Department of Strategy Planning, Far Eastern Memorial Hospital, Banqiao District, New Taipei City 22060, Taiwan)

  • Darsy Darssan

    (School of Public Health, The University of Queensland, Brisbane 4006, Australia)

  • Shamshad Karatela

    (School of Public Health, The University of Queensland, Brisbane 4006, Australia
    Australian Institute of Tropical Health and Medicine (AITHM), James Cook University, Townsville 4870, Australia)

  • Simon A. Reid

    (School of Public Health, The University of Queensland, Brisbane 4006, Australia)

  • Nicholas John Osborne

    (School of Public Health, The University of Queensland, Brisbane 4006, Australia
    European Centre for Environment and Human Health, University of Exeter, Truro TR1 3HD, UK
    School of Population Health, University of NSW, Kensington 2052, Australia)

Abstract

Chronic kidney disease of unknown cause is prevalent in a range of communities; however, its etiology remains unclear. We examined the association between pesticide exposures and the risk of kidney function loss using four waves of the National Health and Nutrition Examination Survey (NHANES) to identify a pathological pathway. We pooled data from four cross-sectional waves of NHANES, with 41,847 participants in total. Exposure to malathion increased the risk of low kidney function (aOR = 1.26, 95% CI = 1.01–1.56) in the adjusted model. Increased risk of low kidney function was not found among those exposed to 2,4-D (aOR = 0.88, 95% CI = 0.72–1.09), 3,5,6-trichloropyridinol (aOR = 0.96, 95% CI = 0.83–1.12), and 3-PBA (aOR = 1.03, 95% CI = 0.94–1.13). Our findings provide evidence of altered kidney function in people exposed to malathion, highlighting the potential of organophosphate pesticides’ role in renal injury.

Suggested Citation

  • En-Tzu Wan & Darsy Darssan & Shamshad Karatela & Simon A. Reid & Nicholas John Osborne, 2021. "Association of Pesticides and Kidney Function among Adults in the US Population 2001–2010," IJERPH, MDPI, vol. 18(19), pages 1-9, September.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:19:p:10249-:d:646138
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