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Effects of Fluoride and Calcium Phosphate-Based Varnishes in Children at High Risk of Tooth Decay: A Randomized Clinical Trial

Author

Listed:
  • Andrea Poza-Pascual

    (Department of Stomatology I, School of Dentistry, University of the Basque Country, 48940 Lejona, Spain)

  • Clara Serna-Muñoz

    (Department of Integrated Pediatric Dentistry, School of Dentistry, University of Murcia, Biomedical Research Institute of Murcia, 30008 Murcia, Spain)

  • Amparo Pérez-Silva

    (Department of Integrated Pediatric Dentistry, School of Dentistry, University of Murcia, Biomedical Research Institute of Murcia, 30008 Murcia, Spain)

  • Yolanda Martínez-Beneyto

    (Department of Integrated Pediatric Dentistry, School of Dentistry, University of Murcia, Biomedical Research Institute of Murcia, 30008 Murcia, Spain)

  • Inmaculada Cabello

    (Department of Integrated Pediatric Dentistry, School of Dentistry, University of Murcia, Biomedical Research Institute of Murcia, 30008 Murcia, Spain)

  • Antonio José Ortiz-Ruiz

    (Department of Integrated Pediatric Dentistry, School of Dentistry, University of Murcia, Biomedical Research Institute of Murcia, 30008 Murcia, Spain)

Abstract

Background: The aim of this study was to investigate the effect of the application of two varnishes—MI Varnish (5% sodium fluoride with CPP-ACP) and Clinpro White Varnish (5% sodium fluoride with fTCP)—applied every three months in children with high caries risk for 12 months on plaque indexes, salivary pH, salivary lactic acid and chemical elements concentrations. Methods: We included 58 children aged 4–12 years, assigned to control (placebo), Clinpro and MI groups. Baseline and three-month saliva samples were taken. We assessed changes in pH, lactic acid concentrations and chemical elements in saliva. Results: At 12 months, all groups showed a nonsignificant increase in pH levels and a reduction in lactic acid, which was greatest in the placebo group. There was a significant reduction in 24 Mg ( p = <0.001), 31 P ( p = 0.033) and 66 Zn ( p = 0.005) levels in the placebo group ( p ≤ 0.05), but not in the other elements studied: 23 Na, 27 Al, 39 K, 44 Ca, 52 Cr, 55 Mn, 57 Fe, 59 Co, 63 Cu, 75 As, 111 Cd, 137 Ba, 208 Pb and 19 F. Conclusions: Neither pH, lactic acid concentrations or most salivary chemical elements were useful in defining patients at high risk of caries or in monitoring the effect of MI Varnish and Clinpro White Varnish after three-month application for 12 months. However, the appearance of new cavities was stopped, and the hygiene index improved, probably due to hygienic and dietary measures and the use of fluoridated toothpaste. Trial registration: ISRCTN registry, ISRCTN13681286.

Suggested Citation

  • Andrea Poza-Pascual & Clara Serna-Muñoz & Amparo Pérez-Silva & Yolanda Martínez-Beneyto & Inmaculada Cabello & Antonio José Ortiz-Ruiz, 2021. "Effects of Fluoride and Calcium Phosphate-Based Varnishes in Children at High Risk of Tooth Decay: A Randomized Clinical Trial," IJERPH, MDPI, vol. 18(19), pages 1-15, September.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:19:p:10049-:d:642293
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    References listed on IDEAS

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    1. Siying Tao & Yan Zhu & He Yuan & Sibei Tao & Yiming Cheng & Jiyao Li & Libang He, 2018. "Efficacy of fluorides and CPP-ACP vs fluorides monotherapy on early caries lesions: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-13, April.
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