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Polystyrene Microplastics Exposure: An Insight into Multiple Organ Histological Alterations, Oxidative Stress and Neurotoxicity in Javanese Medaka Fish ( Oryzias javanicus Bleeker, 1854)

Author

Listed:
  • Sunusi Usman

    (Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400 UPM, Selangor, Malaysia)

  • Ahmad Faizal Abdull Razis

    (Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400 UPM, Selangor, Malaysia
    Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang 43400 UPM, Selangor, Malaysia)

  • Khozirah Shaari

    (Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400 UPM, Selangor, Malaysia
    Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang 43400 UPM, Selangor, Malaysia)

  • Mohammad Noor Azmai Amal

    (Department of Biology, Faculty of Science, Universiti Putra Malaysia, Serdang 43400 UPM, Selangor, Malaysia
    Aquatic Animal Health and Therapeutics Laboratory (Aqua Health), Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400 UPM, Selangor, Malaysia)

  • Mohd Zamri Saad

    (Aquatic Animal Health and Therapeutics Laboratory (Aqua Health), Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400 UPM, Selangor, Malaysia
    Department of Veterinary Laboratory Diagnosis, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang 43400 UPM, Selangor, Malaysia)

  • Nurulfiza Mat Isa

    (Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400 UPM, Selangor, Malaysia
    Laboratory of Vaccines and Biomolecules (VacBio), Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400 UPM, Selangor, Malaysia)

  • Muhammad Farhan Nazarudin

    (Aquatic Animal Health and Therapeutics Laboratory (Aqua Health), Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400 UPM, Selangor, Malaysia)

Abstract

Microplastics (MPs) have become pollutants of concern due to their unknown human health effect and negative impact on terrestrial and aquatic ecosystems. There is increasing number of experimental research on MPs globally with its effects not fully understood; recent animal studies explore its effects on the intestines, yet on other vital organs. Javanese medaka fish was exposed to polystyrene microplastics (PS-MPs) beads for a period of 21 days. Histological alterations, intestinal oxidative stress, permeability and neurotoxicity were evaluated. Significant inflammatory changes and tissue damage were observed in the intestine, liver and kidney. Intestinal oxidative stress and permeability were found to be significantly increased. In the brain, neurotoxicity characterised by a significant induction of oxidative stress, lipid peroxidation and the inhibition of acetylcholinesterase enzyme were elucidated. This study provided an insight into the multiple organ effect of microplastics exposure, necessitating further exploration and identification of biomarkers to be utilised for biomonitoring population at risk in the future.

Suggested Citation

  • Sunusi Usman & Ahmad Faizal Abdull Razis & Khozirah Shaari & Mohammad Noor Azmai Amal & Mohd Zamri Saad & Nurulfiza Mat Isa & Muhammad Farhan Nazarudin, 2021. "Polystyrene Microplastics Exposure: An Insight into Multiple Organ Histological Alterations, Oxidative Stress and Neurotoxicity in Javanese Medaka Fish ( Oryzias javanicus Bleeker, 1854)," IJERPH, MDPI, vol. 18(18), pages 1-13, September.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:18:p:9449-:d:630864
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    References listed on IDEAS

    as
    1. Sunusi Usman & Ahmad Faizal Abdull Razis & Khozirah Shaari & Mohammad Noor Azmai Amal & Mohd Zamri Saad & Nurulfiza Mat Isa & Muhammad Farhan Nazarudin & Syaizwan Zahmir Zulkifli & Jumria Sutra & Musa, 2020. "Microplastics Pollution as an Invisible Potential Threat to Food Safety and Security, Policy Challenges and the Way Forward," IJERPH, MDPI, vol. 17(24), pages 1-24, December.
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