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Chronic Obstructive Pulmonary Disease Increases the Risk of Mortality among Patients with Colorectal Cancer: A Nationwide Population-Based Retrospective Cohort Study

Author

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  • Wei-Jen Cheng

    (Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
    School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
    Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan)

  • Chih-Chao Chiang

    (Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
    Puxin Fengze Chinese Medicine Clinic, Taoyuan 326, Taiwan)

  • Meng-Ting Peng

    (Oncology and Hematology Division, Department of Internal Medicine, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan)

  • Yu-Tung Huang

    (Center for Big Data Analytics and Statistics, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan)

  • Jhen-Ling Huang

    (Center for Big Data Analytics and Statistics, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan)

  • Shang-Hung Chang

    (Center for Big Data Analytics and Statistics, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
    Cardiovascular Division, Department of Internal Medicine, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
    College of Medicine, Chang Gung University, Taoyuan 333, Taiwan)

  • Hsuan-Tzu Yang

    (Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan, 333, Taiwan)

  • Wei-Chun Chen

    (College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
    Gynecologic Oncology Service, Department of Obstetrics and Gynecology, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan)

  • Jong-Jen Kuo

    (Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
    School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
    Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
    Graduate Institute of Traditional Chinese Medicine, School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan)

  • Tsong-Long Hwang

    (Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
    Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
    Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
    Department of Chemical Engineering, Ming-Chi University of Technology, New Taipei 243, Taiwan)

Abstract

Background : Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in Taiwan. Chronic obstructive pulmonary disease (COPD) is associated with CRC mortality in several population-based studies. However, this effect of COPD on CRC shows no difference in some studies and remains unclear in Taiwan’s population. Methods : We conducted a retrospective cohort study using Taiwan’s nationwide database. Patients newly diagnosed with CRC were identified from 2007 to 2012 via the Taiwan Cancer Registry dataset and linked to the National Health Insurance research database to obtain their medical records. Propensity score matching (PSM) was applied at a ratio of 1:2 in COPD and non-COPD patients with CRC. The 5-year overall survival (OS) was analyzed using the Cox regression method. Results : This study included 43,249 patients with CRC, reduced to 13,707 patients after PSM. OS was lower in the COPD group than in the non-COPD group. The adjusted hazard ratio (aHR) for COPD was 1.26 (95% confidence interval (CI), 1.19–1.33). Moreover, patients with CRC plus preexisting COPD showed a higher mortality risk in all stage CRC subgroup analysis. Conclusions : In this 5-year retrospective cohort study, patients with CRC and preexisting COPD had a higher mortality risk than those without preexisting COPD, suggesting these patients need more attention during treatment and follow-up.

Suggested Citation

  • Wei-Jen Cheng & Chih-Chao Chiang & Meng-Ting Peng & Yu-Tung Huang & Jhen-Ling Huang & Shang-Hung Chang & Hsuan-Tzu Yang & Wei-Chun Chen & Jong-Jen Kuo & Tsong-Long Hwang, 2021. "Chronic Obstructive Pulmonary Disease Increases the Risk of Mortality among Patients with Colorectal Cancer: A Nationwide Population-Based Retrospective Cohort Study," IJERPH, MDPI, vol. 18(16), pages 1-12, August.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:16:p:8742-:d:617298
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    Cited by:

    1. Celina I. Valencia & Francine C. Gachupin & Yamilé Molina & Ken Batai, 2022. "Interrogating Patterns of Cancer Disparities by Expanding the Social Determinants of Health Framework to Include Biological Pathways of Social Experiences," IJERPH, MDPI, vol. 19(4), pages 1-11, February.

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