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The Relationship of Tobacco, Alcohol, and Betel Quid with the Formation of Oral Potentially Malignant Disorders: A Community-Based Study from Northeastern Thailand

Author

Listed:
  • Prangtip Worakhajit

    (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand)

  • Pornpoj Fuangtharnthip

    (Department of Advanced General Dentistry, Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand
    Co-authors: Pornpoj Fuangtharnthip, Siribang-on Piboonniyom Khovidhunkit, Pim Chiewwit.)

  • Siribang-on Piboonniyom Khovidhunkit

    (Department of Advanced General Dentistry, Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand
    Co-authors: Pornpoj Fuangtharnthip, Siribang-on Piboonniyom Khovidhunkit, Pim Chiewwit.)

  • Pim Chiewwit

    (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand
    Co-authors: Pornpoj Fuangtharnthip, Siribang-on Piboonniyom Khovidhunkit, Pim Chiewwit.)

  • Boworn Klongnoi

    (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand
    Equal first authors.)

Abstract

This study’s objective was to describe the relationship between the main risk factors for oral cancer, including tobacco (in the form of cigarettes, smokeless tobacco (SLT), secondhand smoking (SS)), alcohol, and betel quid (BQ), and the occurrence of oral potentially malignant disorders (OPMDs). A community-based case-control study was conducted with a population of 1448 adults aged 40 years or above in northeastern Thailand. Patients aged 60 years or above (OR 1.79, p < 0.001) and female patients (OR 2.17, p < 0.001) had a significant chance of having OPMDs. Our multivariate analysis showed that the most potent risk factor for OPMDs occurrence was betel quid (BQ) (adjusted OR 4.65, p < 0.001), followed by alcohol (OR 3.40, p < 0.001). Even former users were at risk of developing OPMDs. The synergistic effect between these main risk factors was significantly shown in the group exposed to SLT, SS, BQ, and alcohol. The most potent synergistic effect was found in the group exposed to SLT, BQ and alcohol with the OR = 20.96.

Suggested Citation

  • Prangtip Worakhajit & Pornpoj Fuangtharnthip & Siribang-on Piboonniyom Khovidhunkit & Pim Chiewwit & Boworn Klongnoi, 2021. "The Relationship of Tobacco, Alcohol, and Betel Quid with the Formation of Oral Potentially Malignant Disorders: A Community-Based Study from Northeastern Thailand," IJERPH, MDPI, vol. 18(16), pages 1-14, August.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:16:p:8738-:d:617203
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    References listed on IDEAS

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    1. Bhawna Gupta & Newell W Johnson, 2014. "Systematic Review and Meta-Analysis of Association of Smokeless Tobacco and of Betel Quid without Tobacco with Incidence of Oral Cancer in South Asia and the Pacific," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-14, November.
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    Cited by:

    1. Peter Bartík & Peter Šagát & Jana Pyšná & Ladislav Pyšný & Jiří Suchý & Zdeněk Trubák & Dominika Petrů, 2023. "The Effect of High Nicotine Dose on Maximum Anaerobic Performance and Perceived Pain in Healthy Non-Smoking Athletes: Crossover Pilot Study," IJERPH, MDPI, vol. 20(2), pages 1-9, January.
    2. Boworn Klongnoi & Vanvisa Sresumatchai & Siribang-on Piboonniyom Khovidhunkit & Pornpoj Fuangtharnthip & Rachatawan Leelarungsun & Binit Shrestha, 2021. "Pilot Model for Community Based Oral Cancer Screening Program: Outcome from 4 Northeastern Provinces in Thailand," IJERPH, MDPI, vol. 18(17), pages 1-12, September.
    3. Ching-Yen Chen & Chen-Chun Lin & Jung-Ta Kao & Wen-Ling Yeh & Chiao-Yun Lin & Yun-Fang Tsai, 2022. "Predicting Hazardous Alcohol Drinking Behaviors in Family Members of Hazardous Alcohol-Drinker Patients," IJERPH, MDPI, vol. 19(9), pages 1-13, May.

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