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The Management of the Cotyledonoid Leiomyoma of the Uterus: A Narrative Review of the Literature

Author

Listed:
  • Francesca Buonomo

    (Institute for Maternal and Child Health, I.R.C.C.S. “Burlo Garofolo”, 34137 Trieste, Italy)

  • Sofia Bussolaro

    (Institute for Maternal and Child Health, I.R.C.C.S. “Burlo Garofolo”, 34137 Trieste, Italy
    Department of Medical, Surgical and Health Science, University of Trieste, 34127 Trieste, Italy)

  • Clarice de Almeida Fiorillo

    (Institute for Maternal and Child Health, I.R.C.C.S. “Burlo Garofolo”, 34137 Trieste, Italy)

  • Giorgio Giorda

    (Centro di Riferimento Oncologico di Aviano (C.R.O.), I.R.C.C.S., 33081 Aviano, Italy)

  • Federico Romano

    (Institute for Maternal and Child Health, I.R.C.C.S. “Burlo Garofolo”, 34137 Trieste, Italy)

  • Stefania Biffi

    (Institute for Maternal and Child Health, I.R.C.C.S. “Burlo Garofolo”, 34137 Trieste, Italy)

  • Giuseppe Ricci

    (Institute for Maternal and Child Health, I.R.C.C.S. “Burlo Garofolo”, 34137 Trieste, Italy
    Department of Medical, Surgical and Health Science, University of Trieste, 34127 Trieste, Italy)

Abstract

Cotyledonoid leiomyoma is an unusual uterine myoma due to some ultrasound features that mimic a malignant lesion facilitating the choice of radical surgery. This study aims to summarize the ultrasound and the magnetic resonance imaging aspects of this atypical lesion, and also discuss surgical treatment and pathological exam. It included all English case reports or case series until August 2021 found through PubMed, Google Scholar, and Scopus. A total of 94 cotyledonoid leiomyomas were reported, with a median tumor size of 12 cm. The typical ultrasound image is characterized by a large solid heterogeneous mass, with high vascularity, no shadowing, and indistinct margins within the myometrium. Magnetic resonance imaging shows the presence of merging isointense nodules to the myometrium in T1-weighted images, hyperintense in T2-weighted images, and contrast agent enhancement. Surgical treatment consists of hysterectomy (75 cases, 80%) or myomectomy (19 cases, 20%), without evidence of recurrence if complete. The placenta-like appearance observed during surgery supports this rare fibroid hypothesis. The intraoperative frozen section can be considered. Microscopically, no atypical cells, signs of mitotic activity or cell necrosis are found. To conclude, some preoperative and intraoperative aspects of this lesion are distinctive and may lead surgeons to opt for conservative surgery.

Suggested Citation

  • Francesca Buonomo & Sofia Bussolaro & Clarice de Almeida Fiorillo & Giorgio Giorda & Federico Romano & Stefania Biffi & Giuseppe Ricci, 2021. "The Management of the Cotyledonoid Leiomyoma of the Uterus: A Narrative Review of the Literature," IJERPH, MDPI, vol. 18(16), pages 1-14, August.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:16:p:8521-:d:613096
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    Cited by:

    1. Antonio Sarría-Santamera & Antonio Simone Laganà & Milan Terzic, 2022. "Women’s Health and Gynecology: Old Challenges and New Insights," IJERPH, MDPI, vol. 19(24), pages 1-6, December.

    More about this item

    Keywords

    cotyledonoid; leiomyoma; US; MRI;
    All these keywords.

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