Author
Listed:
- Xuejie Wang
(Lung Cancer and Muscle Research Group, Pulmonology Department, Hospital del Mar-IMIM, Parc de Salut Mar, 08003 Barcelona, Spain
Department of Medicine, Universitat Autònoma de Barcelona (UAB), 08193 Barcelona, Spain)
- Carmen Villa
(Respiratory Department, Clínica Fuensanta, 28027 Madrid, Spain)
- Yadira Dobarganes
(Respiratory Department, Clínica Fuensanta, 28027 Madrid, Spain)
- Casilda Olveira
(Respiratory Department, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Universidad de Málaga, 29010 Málaga, Spain)
- Rosa Girón
(Respiratory Department, Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, 28006 Madrid, Spain)
- Marta García-Clemente
(Respiratory Department, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain)
- Luis Máiz
(Respiratory Department, Hospital Ramon y Cajal, 28034 Madrid, Spain)
- Oriol Sibila
(Respiratory Department, Hospital Clínic, 08036 Barcelona, Spain
Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain)
- Rafael Golpe
(Respiratory Department, Hospital Lucus Augusti, 27003 Lugo, Spain)
- Rosario Menéndez
(Respiratory Department, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain)
- Juan Rodríguez-López
(Respiratory Department, Hospital San Agustin, Avilés, 33401 Asturias, Spain)
- Concepción Prados
(Respiratory Department, Hospital la Paz, 28046 Madrid, Spain)
- Miguel Angel Martinez-García
(Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
Respiratory Department, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain)
- Juan Luis Rodriguez
(Respiratory Department, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Hospital Clínico San Carlos, 28040 Madrid, Spain
Departament of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain)
- David de la Rosa
(Respiratory Department, Hospital Santa Creu I Sant Pau, 08041 Barcelona, Spain)
- Xavier Duran
(Scientific and Technical Department, Hospital del Mar-IMIM, 08003 Barcelona, Spain)
- Jordi Garcia-Ojalvo
(Department of Health and Experimental Sciences (CEXS), Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain)
- Esther Barreiro
(Lung Cancer and Muscle Research Group, Pulmonology Department, Hospital del Mar-IMIM, Parc de Salut Mar, 08003 Barcelona, Spain
Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
Department of Health and Experimental Sciences (CEXS), Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain)
Abstract
Whether high blood eosinophil counts may define a better phenotype in bronchiectasis patients, as shown in chronic obstructive pulmonary disease (COPD), remains to be investigated. Differential phenotypic characteristics according to eosinophil counts were assessed using a biostatistical approach in a large cohort study from the Spanish Online Bronchiectasis Registry (RIBRON). The 906 patients who met the inclusion criteria were clustered into two groups on the basis of their eosinophil levels. The potential differences according to the bronchiectasis severity index (BSI) score between two groups (Mann–Whitney U test and eosinophil count threshold: 100 cells/µL) showed the most balanced cluster sizes: above-threshold and below-threshold groups. Patients above the threshold exhibited significantly better clinical outcomes, lung function, and nutritional status, while showing lower systemic inflammation levels. The proportion of patients with mild disease was higher in the above-threshold group, while the below-threshold patients were more severe. Two distinct clinical phenotypes of stable patients with non-cystic fibrosis (CF) bronchiectasis of a wide range of disease severity were established on the basis of blood eosinophil counts using a biostatistical approach. Patients classified within the above-threshold cluster were those exhibiting a mild disease, significantly better clinical outcomes, lung function, and nutritional status while showing lower systemic inflammatory levels. These results will contribute to better characterizing bronchiectasis patients into phenotypic profiles with their clinical implications.
Suggested Citation
Xuejie Wang & Carmen Villa & Yadira Dobarganes & Casilda Olveira & Rosa Girón & Marta García-Clemente & Luis Máiz & Oriol Sibila & Rafael Golpe & Rosario Menéndez & Juan Rodríguez-López & Concepción P, 2021.
"Phenotypic Clustering in Non-Cystic Fibrosis Bronchiectasis Patients: The Role of Eosinophils in Disease Severity,"
IJERPH, MDPI, vol. 18(16), pages 1-16, August.
Handle:
RePEc:gam:jijerp:v:18:y:2021:i:16:p:8431-:d:611623
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