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The Onset of Depression in Middle-Aged Presumed Healthy Slovenian Family Practice Attendees and Its Associations with Genetic Risk Assessment, Quality of Life and Health Status: A Contribution for Family Medicine Practitioners’ Early Detection

Author

Listed:
  • Nina Jerala

    (Faculty of Medicine, Department of Family Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia)

  • Polona Selič-Zupančič

    (Faculty of Medicine, Department of Family Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia)

Abstract

Despite depression being a major driver of morbidity and mortality, the majority of primary care patients remain undiagnosed, so this study aimed to assess the prevalence of depression and the association with demographic and clinical variables, genetic risk, and quality of life. The participants were presumably healthy model family medicine practice (MFMP) attendees between 30 and 65 years of age and recruited during a preventive check-up in 2019. Each of the 40 pre-selected MFMP pragmatically invited 30 attendees to voluntarily participate. They completed a questionnaire of demographic, clinical, and social determinants, as well as a three-generational family history. The results were analyzed using multivariable modelling to calculate the associations with signs of depression. A modified Scheuner method was used to calculate the level genetic risk level using family history. Of 968 participants, aged 42.8 ± 8.6 years, 627 (64.8%) were women. The prevalence of depression was 4.1%. Signs of depression were negatively associated with health-related quality of life score, in particular in the domains of self-care ( p = 0.001) and anxiety/depression ( p < 0.001). Depression was also associated with predicted high risk for comorbidities given the family history ( p = 0.030). Primary care directed at improving patients’ quality of life should implement more widespread screening for mental health disorders. Family history for disease even beyond depression can be used by physicians as an important primary prevention tool.

Suggested Citation

  • Nina Jerala & Polona Selič-Zupančič, 2021. "The Onset of Depression in Middle-Aged Presumed Healthy Slovenian Family Practice Attendees and Its Associations with Genetic Risk Assessment, Quality of Life and Health Status: A Contribution for Fam," IJERPH, MDPI, vol. 18(15), pages 1-13, August.
  • Handle: RePEc:gam:jijerp:v:18:y:2021:i:15:p:8197-:d:607251
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    References listed on IDEAS

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    1. Bach Xuan Tran & Long Hoang Nguyen & Ngoc Minh Pham & Huyen Thanh Thi Vu & Hung Trong Nguyen & Duong Huong Phan & Giang Hai Ha & Hai Quang Pham & Thao Phuong Nguyen & Carl A. Latkin & Cyrus S.H. Ho & , 2020. "Global Mapping of Interventions to Improve Quality of Life of People with Diabetes in 1990–2018," IJERPH, MDPI, vol. 17(5), pages 1-14, March.
    2. Nena Kopčavar Guček & Polona Selič, 2018. "Depression in Intimate Partner Violence Victims in Slovenia: A Crippling Pattern of Factors Identified in Family Practice Attendees," IJERPH, MDPI, vol. 15(2), pages 1-16, January.
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