IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i15p8195-d607247.html
   My bibliography  Save this article

Hair Lead, Aluminum, and Other Toxic Metals in Normal-Weight and Obese Patients with Coronary Heart Disease

Author

Listed:
  • Anatoly V. Skalny

    (World-Class Research Center “Digital Biodesign and Personalized Healthcare”, IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia
    Department of Bioelementology, KG Razumovsky Moscow State University of Technologies and Management, 109004 Moscow, Russia)

  • Philippe Yu Kopylov

    (World-Class Research Center “Digital Biodesign and Personalized Healthcare”, IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia)

  • Monica M. B. Paoliello

    (Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, NY 10461, USA
    Graduate Program in Public Health, Center of Health Sciences, State University of Londrina, Londrina 86057-970, Brazil)

  • Jung-Su Chang

    (College of Nutrition, Taipei Medical University, Taipei 110, Taiwan
    College of Public Health, Taipei Medical University, Taipei 110, Taiwan)

  • Michael Aschner

    (Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, NY 10461, USA
    Laboratory of Molecular Dietetics, IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia)

  • Igor P. Bobrovnitsky

    (Laboratory of Molecular Dietetics, IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia
    Centre for Strategic Planning of FMBA of Russia, 123182 Moscow, Russia)

  • Jane C.-J. Chao

    (College of Nutrition, Taipei Medical University, Taipei 110, Taiwan
    Nutrition Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan)

  • Jan Aaseth

    (College of Public Health, Taipei Medical University, Taipei 110, Taiwan
    Research Department, Innlandet Hospital Trust, 2380 Brumunddal, Norway)

  • Sergei N. Chebotarev

    (Department of Bioelementology, KG Razumovsky Moscow State University of Technologies and Management, 109004 Moscow, Russia)

  • Alexey A. Tinkov

    (College of Public Health, Taipei Medical University, Taipei 110, Taiwan
    Laboratory of Ecobiomonitoring and Quality Control, Yaroslavl State University, 150003 Yaroslavl, Russia)

Abstract

The objective of the present study was to evaluate hair toxic metal levels in patients with obesity and/or coronary heart disease (CHD). Following a 2 × 2 factorial design, subjects without CHD were grouped into normal weight control ( n = 123) and obese groups ( n = 140). Patients suffering from CHD were divided into normal weight ( n = 180) and obese CHD subjects ( n = 240). Hair Al, As, Cd, Hg, Ni, and Pb levels were evaluated using inductively-coupled plasma mass-spectrometry. The data demonstrate that hair Al and Hg levels were higher in obese subjects as compared to normal weight controls. Normal weight CHD patients were characterized by significantly higher hair Al, As, Cd, and Pb levels when compared to healthy subjects. The highest hair Al, As, and Pb levels were observed in obese CHD patients, significantly exceeding the respective values in other groups. Factorial analysis revealed significant influence of factorial interaction (CHD*obesity) only for hair Pb content. Given the role of obesity as a risk factor for CHD, it is proposed that increased toxic metal accumulation in obesity may promote further development of cardiovascular diseases.

Suggested Citation

  • Anatoly V. Skalny & Philippe Yu Kopylov & Monica M. B. Paoliello & Jung-Su Chang & Michael Aschner & Igor P. Bobrovnitsky & Jane C.-J. Chao & Jan Aaseth & Sergei N. Chebotarev & Alexey A. Tinkov, 2021. "Hair Lead, Aluminum, and Other Toxic Metals in Normal-Weight and Obese Patients with Coronary Heart Disease," IJERPH, MDPI, vol. 18(15), pages 1-11, August.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:15:p:8195-:d:607247
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/15/8195/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/15/8195/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:15:p:8195-:d:607247. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.