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Myostatin/Appendicular Skeletal Muscle Mass (ASM) Ratio, Not Myostatin, Is Associated with Low Handgrip Strength in Community-Dwelling Older Women

Author

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  • Soo Jeong Choi

    (Division of Nephrology, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon 14584, Korea)

  • Min Sung Lee

    (Division of Nephrology, Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul 07804, Korea)

  • Duk-Hee Kang

    (Division of Nephrology, Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul 07804, Korea)

  • Gang Jee Ko

    (Division of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Seoul 08308, Korea)

  • Hee-Sook Lim

    (Department of Food Sciences and Nutrition, Yeonsung University, Anyang 14011, Korea)

  • Byung Chul Yu

    (Division of Nephrology, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon 14584, Korea)

  • Moo Yong Park

    (Division of Nephrology, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon 14584, Korea)

  • Jin Kuk Kim

    (Division of Nephrology, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon 14584, Korea)

  • Chul-Hee Kim

    (Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon 14854, Korea)

  • Seung Duk Hwang

    (Division of Nephrology, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon 14584, Korea)

  • Jun Chul Kim

    (Division of Nephrology, Department of Internal Medicine, CHA University School of Medicine, Gumi 39295, Korea)

  • Chang Won Won

    (Department of Family Medicine, Kyung Hee University School of Medicine, Seoul 02447, Korea
    These authors contributed equally to this work and should be considered co-corresponding authors.)

  • Won Suk An

    (Division of Nephrology, Department of Internal Medicine, Dong-A University College of Medicine, Busan 49201, Korea
    These authors contributed equally to this work and should be considered co-corresponding authors.)

Abstract

Background/Aims: Elevated levels of serum myostatin have been proposed as a biomarker for sarcopenia. Recent studies have shown that elevated level of serum myostatin was associated with physical fitness and performance. This study aimed to examine the significance of myostatin in the association between muscle mass and physical performance in the elderly. Methods: This cross-sectional study is based on the Korean Frailty and Aging Cohort study involving 1053 people aged 70 years or over. Anthropometric, physical performance, and laboratory data were collected. Results: The mean age of the participants was 75.8 years, and 50.7% of them were female. Serum myostatin levels in men (3.7 ± 1.2 vs. 3.2 ± 1.1 ng/mL, p < 0.001) were higher compared with that in women. Serum myostatin level was associated with appendicular skeletal muscle mass (ASM) index and eGFR by cystatin C. Serum myostatin/ASM ratio was associated with handgrip strength in women. Conclusion: Higher serum myostatin levels were related with higher muscle mass and better physical performances in the elderly. Serum myostatin/ASM ratio may be a predictor for physical performance rather than myostatin.

Suggested Citation

  • Soo Jeong Choi & Min Sung Lee & Duk-Hee Kang & Gang Jee Ko & Hee-Sook Lim & Byung Chul Yu & Moo Yong Park & Jin Kuk Kim & Chul-Hee Kim & Seung Duk Hwang & Jun Chul Kim & Chang Won Won & Won Suk An, 2021. "Myostatin/Appendicular Skeletal Muscle Mass (ASM) Ratio, Not Myostatin, Is Associated with Low Handgrip Strength in Community-Dwelling Older Women," IJERPH, MDPI, vol. 18(14), pages 1-11, July.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:14:p:7344-:d:591299
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    References listed on IDEAS

    as
    1. Shozo Yano & Atsushi Nagai & Minoru Isomura & Masayuki Yamasaki & Tsunetaka Kijima & Miwako Takeda & Tsuyoshi Hamano & Toru Nabika, 2015. "Relationship between Blood Myostatin Levels and Kidney Function:Shimane CoHRE Study," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-9, October.
    2. Myong-Won Seo & Sung-Woo Jung & Sung-Woo Kim & Hyun Chul Jung & Deog-Yoon Kim & Jong Kook Song, 2020. "Comparisons of Muscle Quality and Muscle Growth Factor Between Sarcopenic and Non-Sarcopenic Older Women," IJERPH, MDPI, vol. 17(18), pages 1-13, September.
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