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Quantitation of Silica Contents in Lung Explants of Transplanted Patients: Artificial Stone-Induced Silicosis vs. Idiopathic Pulmonary Fibrosis

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  • Elizabeth Fireman

    (Laboratory for Pulmonary and Allergic Diseases, Tel-Aviv Medical Centre, Tel-Aviv 6423906, Israel
    Environmental and Occupational Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel)

  • Abed Elrahman Mahamed

    (Laboratory for Pulmonary and Allergic Diseases, Tel-Aviv Medical Centre, Tel-Aviv 6423906, Israel
    Environmental and Occupational Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel
    Institute of Pulmonary Diseases, Rabin Medical Centre, Petah Tekvah 4947492, Israel, both affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel)

  • Dror Rosengarten

    (Institute of Pulmonary Diseases, Rabin Medical Centre, Petah Tekvah 4947492, Israel, both affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel
    These authors contributed equally.)

  • Noa Noach Ophir

    (Laboratory for Pulmonary and Allergic Diseases, Tel-Aviv Medical Centre, Tel-Aviv 6423906, Israel
    Environmental and Occupational Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel)

  • Mordechai Reuven Kramer

    (Institute of Pulmonary Diseases, Rabin Medical Centre, Petah Tekvah 4947492, Israel, both affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel
    These authors contributed equally.)

Abstract

Spectrophotometric techniques provide qualitative but not quantitative data on lung particles. We aimed to quantitate silica content in biopsies of lung-transplanted silicosis patients by applying X-ray fluorescence (XRF) spectrometry. Lung biopsies of 17 lung-transplanted artificial patients were quantitated for silica and other minerals particles by Niton XL3 XRF spectrometry. Occupational and clinical history data were assessed. Lung biopsies of artificial stone-induced silicosis (ASIS) patients contained significantly higher levels of silica compared to those of idiopathic pulmonary fibrosis (IPF) patients (7284.29 ± 4693.75 ppm vs. 898.88 ± 365.66 ppm, p < 0.0001). Silica content correlated negatively with age, body mass index, and pulmonary function test results. A 1128 ppm silica cut-off value yielded 100% sensitivity and 94% specificity for predicting ASIS (AUC = 0.94, p < 0.0001). In conclusion, XRF measurements in lung biopsies can differentiate between silica and mineral particles in ASIS and IPF.

Suggested Citation

  • Elizabeth Fireman & Abed Elrahman Mahamed & Dror Rosengarten & Noa Noach Ophir & Mordechai Reuven Kramer, 2021. "Quantitation of Silica Contents in Lung Explants of Transplanted Patients: Artificial Stone-Induced Silicosis vs. Idiopathic Pulmonary Fibrosis," IJERPH, MDPI, vol. 18(14), pages 1-8, July.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:14:p:7237-:d:589499
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