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Influence of Menstrual Cycle Estradiol-β-17 Fluctuations on Energy Substrate Utilization-Oxidation during Aerobic, Endurance Exercise

Author

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  • Hannah N. Willett

    (Department of Exercise & Sport Science, University of North Carolina, Chapel Hill, NC 27599, USA)

  • Kristen J. Koltun

    (Department of Sports Medicine and Nutrition, University of Pittsburgh, Pittsburgh, PA 15203, USA)

  • Anthony C. Hackney

    (Department of Exercise & Sport Science, University of North Carolina, Chapel Hill, NC 27599, USA
    Department of Nutrition, Gillings school of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA)

Abstract

This study examined the effect of estradiol-β-17 across the menstrual cycle (MC) during aerobic exercise on energy substrate utilization and oxidation. Thirty-two eumenorrheic (age = 22.4 ± 3.8 y (mean ± SD)), physically active women participated in two steady-state running sessions at 65% of VO 2max , one during the early follicular and one during the luteal phase of the MC. Blood samples were collected at rest before each exercise session and analyzed for Estradiol-β-17 to confirm the MC phase. Carbohydrate (CHO) utilization and oxidation values were significantly lower ( p < 0.05) in the luteal (utilization: 51.6 ± 16.7%; oxidation: 1.22 ± 0.56 g/min; effect size (ES) = 0.45, 0.27) than follicular phase (utilization: 58.2 ± 15.1%; oxidation: 1.38 ± 0.60 g/min) exercise sessions. Conversely, fat utilization and oxidation values were significantly ( p < 0.05) higher in the luteal (utilization: 48.4 ± 16.7%; oxidation: 0.49 ± 0.19 g/min; ES = 0.45,0.28) than follicular phase (utilization: 41.8 ± 15.1%; oxidation: 0.41 ± 0.14 g/min). Estradiol-β-17 concentrations were significantly ( p < 0.01) greater during the luteal (518.5 ± 285.4 pmol/L; ES = 0.75) than follicular phase (243.8 ± 143.2 pmol/L). Results suggest a greater use of fat and reduced amount of CHO usage during the luteal versus follicular phase, directly related to the change in resting estradiol-β-17. Future research should investigate the role these changes may play in female athletic performance.

Suggested Citation

  • Hannah N. Willett & Kristen J. Koltun & Anthony C. Hackney, 2021. "Influence of Menstrual Cycle Estradiol-β-17 Fluctuations on Energy Substrate Utilization-Oxidation during Aerobic, Endurance Exercise," IJERPH, MDPI, vol. 18(13), pages 1-6, July.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:13:p:7209-:d:589049
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