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Gender Difference in the Relationships between Inflammatory Markers, Serum Uric Acid and Framingham Risk Score

Author

Listed:
  • Jui-Hua Huang

    (Department of Golden-Ager Industry Management, Chaoyang University of Technology, Taichung 413, Taiwan
    Occupational Health Center, Changhua Christian Hospital, Changhua 500, Taiwan)

  • Ren-Hau Li

    (Department of Psychology, Chung Shan Medical University, Taichung 402, Taiwan)

  • Shu-Ling Huang

    (Department of Psychology, Chung Shan Medical University, Taichung 402, Taiwan
    Room of Clinical Psychology, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Hon-Ke Sia

    (Division of Endocrinology and Metabolism, Changhua Christian Hospital, Changhua 500, Taiwan
    Department of Healthcare Administration, Asia University, 500 Lioufong Rd., Wufeng, Taichung 41354, Taiwan)

  • Chao-Hung Yu

    (Division of Cardiovascular Medicine, Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, Taiwan)

  • Feng-Cheng Tang

    (Department of Leisure Services Management, Chaoyang University of Technology, Taichung 413, Taiwan
    Department of Occupational Medicine, Changhua Christian Hospital, Changhua 500, Taiwan
    School of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan)

Abstract

The purpose of the present study was to explore the role of gender in the relation of high-sensitivity C-reactive protein (hsCRP), white blood cell (WBC) count, and serum uric acid (UA) to the risk of future cardiovascular disease (CVD) events. In total, 404 workers were recruited to obtain the measurements of serum markers for CVD risk. Demographic data, nutrition, exercise, smoking, and alcohol consumption were assessed through a questionnaire. The Framingham Risk Score (FRS) was adopted to estimate the risk of future CVD events. Multiple linear regression models were used to determine CVD risk markers in relation to the FRS by gender. The hsCRP was not significantly correlated with the FRS for all workers after adjusting for covariates, including demographic data and health-related lifestyle. WBC count was positively correlated with FRS for all workers, but WBC count did not show an interaction with gender with respect to the FRS. Serum UA showed an interaction with gender on the FRS, and UA positively correlated with the FRS in males though not in females. With respect to CVD prevention, the WBC count can be used to monitor the risk for all workers. Due to a gender difference shown in the relationship between serum UA and the FRS, serum UA can be a monitor of the risk of future CVD events in male workers only.

Suggested Citation

  • Jui-Hua Huang & Ren-Hau Li & Shu-Ling Huang & Hon-Ke Sia & Chao-Hung Yu & Feng-Cheng Tang, 2021. "Gender Difference in the Relationships between Inflammatory Markers, Serum Uric Acid and Framingham Risk Score," IJERPH, MDPI, vol. 18(13), pages 1-10, July.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:13:p:7103-:d:587588
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    Cited by:

    1. Domenico Di Raimondo & Gaia Musiari & Giuliana Rizzo & Edoardo Pirera & Salvatore Santo Signorelli, 2022. "New Insights in Prevention and Treatment of Cardiovascular Disease," IJERPH, MDPI, vol. 19(4), pages 1-7, February.

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