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Anti-TNF-Related Leukocytoclastic Vasculitis in Ulcerative Colitis: A Case Report

Author

Listed:
  • Valentina Giorgio

    (Department of Life Sciences and Global Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
    These two authors equally contributed to this paper.)

  • Elisa Blasi

    (Department of Life Sciences and Global Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
    These two authors equally contributed to this paper.)

  • Donato Rigante

    (Department of Life Sciences and Global Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
    Università Cattolica Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy)

  • Cristina Guerriero

    (Institute of Dermatology, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy)

  • Clara De Simone

    (Università Cattolica Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
    Institute of Dermatology, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy)

  • Anna Laura Fedele

    (Institute of Rheumatology, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy)

  • Giuseppe Stella

    (Department of Life Sciences and Global Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy)

  • Antonio Gasbarrini

    (Università Cattolica Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
    Department of Internal Medicine, Università Cattolica Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy)

  • Franco Scaldaferri

    (Department of Internal Medicine, Università Cattolica Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy)

Abstract

Background: The development of drugs directed against tumor necrosis factor (TNF)-α has dramatically modified the therapeutic approach to inflammatory bowel diseases: a larger use of such drugs has also led to a major knowledge about their adverse effects, especially on skin. The aim of this report was to describe a rare steroid-dependent form of leukocytoclastic vasculitis induced by an anti-TNF-α agent in a young woman with ulcerative colitis. Case presentation: A young girl with ulcerative colitis developed a form of leukocytoclastic vasculitis induced by an anti-TNF-α agent. Recurrent palpable purpuric lesions on her legs were the main cutaneous manifestation. Skin lesions were steroid-dependent, but improved after withdrawal of the anti-TNF-α agent and second-line immunosuppressant therapy. Conclusions: The need to develop specific recommendations to guide the use of medications for managing skin reactions induced by anti-TNF-α drugs is herein emphasized.

Suggested Citation

  • Valentina Giorgio & Elisa Blasi & Donato Rigante & Cristina Guerriero & Clara De Simone & Anna Laura Fedele & Giuseppe Stella & Antonio Gasbarrini & Franco Scaldaferri, 2021. "Anti-TNF-Related Leukocytoclastic Vasculitis in Ulcerative Colitis: A Case Report," IJERPH, MDPI, vol. 18(13), pages 1-6, June.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:13:p:6711-:d:579637
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