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Prenatal Particulate Matter (PM) Exposure and Natriuretic Peptides in Newborns from Mexico City

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  • Abigail Muñoz-Rodríguez

    (Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Apartado Postal 70228, Ciudad de México 04510, Mexico)

  • Jorge Alfonso Maciel-Ruiz

    (Instituto Nacional de Cancerología (INCan), Subdirección de Investigación Básica, Ciudad de México 14080, Mexico)

  • Ana María Salazar

    (Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Apartado Postal 70228, Ciudad de México 04510, Mexico)

  • Monserrat Sordo

    (Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Apartado Postal 70228, Ciudad de México 04510, Mexico)

  • Patricia Ostrosky-Wegman

    (Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Apartado Postal 70228, Ciudad de México 04510, Mexico)

  • Jorge H. Limón-Pacheco

    (Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Apartado Postal 70228, Ciudad de México 04510, Mexico)

  • Andrés Eduardo Nepomuceno-Hernández

    (Centro de Investigación Materno Infantil del Grupo de Estudios al Nacimiento, Asociación Hispano Mexicana, Ciudad de México 09880, Mexico)

  • Rodrigo Ayala-Yáñez

    (Centro de Investigación Materno Infantil del Grupo de Estudios al Nacimiento, Asociación Hispano Mexicana, Ciudad de México 09880, Mexico)

  • María Eugenia Gonsebatt

    (Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Apartado Postal 70228, Ciudad de México 04510, Mexico)

  • Citlalli Osorio-Yáñez

    (Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Apartado Postal 70228, Ciudad de México 04510, Mexico)

Abstract

(1) Background: The aim of this study was to assess associations between particulate matter (PM) exposure and natriuretic peptide concentrations in cord blood from newborns. (2) Methods: we conducted a cross-sectional study in Mexico City with 101 pregnant women from CIMIGEN Hospital. Atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) were measured in plasma from cord blood in 51 newborns by ELISA. We estimated PM exposure (PM2.5 and PM10) at first, second and third trimester of pregnancy. (3) Results: The median and interquartile range for ANP, BNP and CNP plasma concentrations were 66.71 (46.92–80.23), 98.23 (73.64–112.30) and 1129.11 (944.10–1452.02) pg/mL, respectively. PM2.5 and PM10 levels for the whole pregnancy period were 22.2 µg/m 3 and 41.63 µg/m 3 , respectively. Employing multivariable linear regression models adjusted for maternal age, newborn sex, smoking before pregnancy, maternal occupation and newborns’ length and height, we observed a 2.47 pg/mL (95%CI: −4.67, −0.27) decrease in BNP associated with PM2.5 exposure during second trimester. Adjusted for the same set of confounders, third trimester PM10 exposure was inversely associated with ANP concentrations (beta estimate: −0.90; 95% CI: −1.80, −0.03). Neither PM10 nor PM2.5 were associated with CNP at any trimester of pregnancy. (4) Conclusions: Prenatal exposure to particulate matter was associated with ANP and BNP decrease in newborns.

Suggested Citation

  • Abigail Muñoz-Rodríguez & Jorge Alfonso Maciel-Ruiz & Ana María Salazar & Monserrat Sordo & Patricia Ostrosky-Wegman & Jorge H. Limón-Pacheco & Andrés Eduardo Nepomuceno-Hernández & Rodrigo Ayala-Yáñe, 2021. "Prenatal Particulate Matter (PM) Exposure and Natriuretic Peptides in Newborns from Mexico City," IJERPH, MDPI, vol. 18(12), pages 1-12, June.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:12:p:6546-:d:576979
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    References listed on IDEAS

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    1. Adrián Giovani Trejo-González & Horacio Riojas-Rodriguez & José Luis Texcalac-Sangrador & Carlos Manuel Guerrero-López & Karla Cervantes-Martínez & Magali Hurtado-Díaz & Luz Angélica de la Sierra-de l, 2019. "Quantifying health impacts and economic costs of PM2.5 exposure in Mexican cities of the National Urban System," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 64(4), pages 561-572, May.
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