IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i12p6239-d571734.html
   My bibliography  Save this article

Polydisperse Aerosol Transport and Deposition in Upper Airways of Age-Specific Lung

Author

Listed:
  • Mohammad S. Islam

    (School of Mechanical and Mechatronic Engineering, University of Technology Sydney (UTS), 15 Broadway, Ultimo, NSW 2007, Australia)

  • Puchanee Larpruenrudee

    (School of Mechanical and Mechatronic Engineering, University of Technology Sydney (UTS), 15 Broadway, Ultimo, NSW 2007, Australia)

  • Sheikh I. Hossain

    (School of Life Sciences, University of Technology Sydney, Ultimo, NSW 2007, Australia)

  • Mohammad Rahimi-Gorji

    (Department of Human Structure and Repair, Ghent University, 9000 Ghent, Belgium)

  • Yuantong Gu

    (School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia)

  • Suvash C. Saha

    (School of Mechanical and Mechatronic Engineering, University of Technology Sydney (UTS), 15 Broadway, Ultimo, NSW 2007, Australia)

  • Gunther Paul

    (Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, QLD 4810, Australia)

Abstract

A comprehensive understanding of airflow characteristics and particle transport in the human lung can be useful in modelling to inform clinical diagnosis, treatment, and management, including prescription medication and risk assessment for rehabilitation. One of the difficulties in clinical treatment of lung disorders lies in the patients’ variable physical lung characteristics caused by age, amongst other factors, such as different lung sizes. A precise understanding of the comparison between different age groups with various flow rates is missing in the literature, and this study aims to analyse the airflow and aerosol transport within the age-specific lung. ANSYS Fluent solver and the large-eddy simulation (LES) model were employed for the numerical simulation. The numerical model was validated with the available literature and the computational results showed airway size-reduction significantly affected airflow and particle transport in the upper airways. This study reports higher deposition at the mouth-throat region for larger diameter particles. The overall deposition efficiency (DE) increased with airway size reduction and flow rate. Lung aging effected the pressure distribution and a higher pressure drop was reported for the aged lung as compared to the younger lung. These findings could inform medical management through individualised simulation of drug-aerosol delivery processes for the patient-specific lung.

Suggested Citation

  • Mohammad S. Islam & Puchanee Larpruenrudee & Sheikh I. Hossain & Mohammad Rahimi-Gorji & Yuantong Gu & Suvash C. Saha & Gunther Paul, 2021. "Polydisperse Aerosol Transport and Deposition in Upper Airways of Age-Specific Lung," IJERPH, MDPI, vol. 18(12), pages 1-17, June.
  • Handle: RePEc:gam:jijerp:v:18:y:2021:i:12:p:6239-:d:571734
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/12/6239/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/18/12/6239/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Mohammad S. Islam & Gunther Paul & Hui X. Ong & Paul M. Young & Y. T. Gu & Suvash C. Saha, 2020. "A Review of Respiratory Anatomical Development, Air Flow Characterization and Particle Deposition," IJERPH, MDPI, vol. 17(2), pages 1-28, January.
    2. Mohammad S. Islam & YuanTong Gu & Arpad Farkas & Gunther Paul & Suvash C. Saha, 2020. "Helium–Oxygen Mixture Model for Particle Transport in CT-Based Upper Airways," IJERPH, MDPI, vol. 17(10), pages 1-19, May.
    3. Michael Hendryx & Mohammad Saidul Islam & Guang-Hui Dong & Gunther Paul, 2020. "Air Pollution Emissions 2008–2018 from Australian Coal Mining: Implications for Public and Occupational Health," IJERPH, MDPI, vol. 17(5), pages 1-11, February.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Mohammad S. Islam & Tianxin Fang & Callum Oldfield & Puchanee Larpruenrudee & Hamidreza Mortazavy Beni & Md. M. Rahman & Shahid Husain & Yuantong Gu, 2022. "Heat Wave and Bushfire Meteorology in New South Wales, Australia: Air Quality and Health Impacts," IJERPH, MDPI, vol. 19(16), pages 1-29, August.
    2. Bao V. Duong & Puchanee Larpruenrudee & Tianxin Fang & Sheikh I. Hossain & Suvash C. Saha & Yuantong Gu & Mohammad S. Islam, 2022. "Is the SARS CoV-2 Omicron Variant Deadlier and More Transmissible Than Delta Variant?," IJERPH, MDPI, vol. 19(8), pages 1-25, April.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Mohammad S. Islam & Tianxin Fang & Callum Oldfield & Puchanee Larpruenrudee & Hamidreza Mortazavy Beni & Md. M. Rahman & Shahid Husain & Yuantong Gu, 2022. "Heat Wave and Bushfire Meteorology in New South Wales, Australia: Air Quality and Health Impacts," IJERPH, MDPI, vol. 19(16), pages 1-29, August.
    2. Bao V. Duong & Puchanee Larpruenrudee & Tianxin Fang & Sheikh I. Hossain & Suvash C. Saha & Yuantong Gu & Mohammad S. Islam, 2022. "Is the SARS CoV-2 Omicron Variant Deadlier and More Transmissible Than Delta Variant?," IJERPH, MDPI, vol. 19(8), pages 1-25, April.
    3. Parth Singh & Vishnu Raghav & Vignesh Padhmashali & Gunther Paul & Mohammad S. Islam & Suvash C. Saha, 2020. "Airflow and Particle Transport Prediction through Stenosis Airways," IJERPH, MDPI, vol. 17(3), pages 1-19, February.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:12:p:6239-:d:571734. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.