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The Rare, Unexpected Condition of a Twisted Leiomyoma in Mayer-Rokitansky-Küster-Hauser (MRKH) Syndrome: Etiopathogenesis, Diagnosis and Management. Our Experience and Narrative Review of the Literature

Author

Listed:
  • Federico Romano

    (Institute for Maternal and Child Health, I.R.C.C.S. “Burlo Garofolo”, 34100 Trieste, Italy)

  • Stefania Carlucci

    (Department of Obstetrics and Gynecology, Azienda Sanitaria Universitaria Giuliano-Isontina, San Polo Hospital, Gorizia-Monfalcone, 34127 Trieste, Italy)

  • Guglielmo Stabile

    (Institute for Maternal and Child Health, I.R.C.C.S. “Burlo Garofolo”, 34100 Trieste, Italy)

  • Giuseppe Mirenda

    (Clinical Department of Medical, Surgical and Health Sciences, University of Trieste, 34137 Trieste, Italy)

  • Mariateresa Mirandola

    (Clinical Department of Medical, Surgical and Health Sciences, University of Trieste, 34137 Trieste, Italy)

  • Francesco Paolo Mangino

    (Institute for Maternal and Child Health, I.R.C.C.S. “Burlo Garofolo”, 34100 Trieste, Italy)

  • Andrea Romano

    (UCO Pathological Anatomy and Histology, Azienda Ospedaliera-Universitaria Ospedali Riuniti, 34129 Trieste, Italy)

  • Giuseppe Ricci

    (Institute for Maternal and Child Health, I.R.C.C.S. “Burlo Garofolo”, 34100 Trieste, Italy
    Clinical Department of Medical, Surgical and Health Sciences, University of Trieste, 34137 Trieste, Italy)

Abstract

Uterine leiomyomas are a common finding in medical practice, but their frequency changes drastically when contextualized in a syndrome, as in the following case. A 50-year-old woman with a known Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome presented at our clinic with abdominal pain located in the lower quadrants and scarcely responsive to analgesic therapy. A twisted gynecological pelvic mass was diagnosed, and management for prompt resolution was adopted. Histologically the mass was described as a leiomyoma. The aim of the present study is to share our experience and to review the literature to compare different manifestation of the disease and different approach used in the various centers. The additional novelty of the paper is the immunohistochemical study we carried out on the leiomyoma that is contrasted with the current etiopathogenetic theories.

Suggested Citation

  • Federico Romano & Stefania Carlucci & Guglielmo Stabile & Giuseppe Mirenda & Mariateresa Mirandola & Francesco Paolo Mangino & Andrea Romano & Giuseppe Ricci, 2021. "The Rare, Unexpected Condition of a Twisted Leiomyoma in Mayer-Rokitansky-Küster-Hauser (MRKH) Syndrome: Etiopathogenesis, Diagnosis and Management. Our Experience and Narrative Review of the Literatu," IJERPH, MDPI, vol. 18(11), pages 1-13, May.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:11:p:5895-:d:566021
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    Cited by:

    1. Antonio Sarría-Santamera & Antonio Simone Laganà & Milan Terzic, 2022. "Women’s Health and Gynecology: Old Challenges and New Insights," IJERPH, MDPI, vol. 19(24), pages 1-6, December.

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