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The Acute Effect of Magnesium Supplementation on Endothelial Function: A Randomized Cross-Over Pilot Study

Author

Listed:
  • Caitríona Murphy

    (Clinical and Health Sciences, University of South Australia, Adelaide, SA 5001, Australia
    Department of Biological Sciences, Technological University Dublin, D07 EWV4 Dublin, Ireland)

  • Jennifer Byrne

    (Clinical and Health Sciences, University of South Australia, Adelaide, SA 5001, Australia
    Department of Biological Sciences, Technological University Dublin, D07 EWV4 Dublin, Ireland)

  • Jennifer B. Keogh

    (Clinical and Health Sciences, University of South Australia, Adelaide, SA 5001, Australia)

  • Michelle L. Headland

    (Clinical and Health Sciences, University of South Australia, Adelaide, SA 5001, Australia)

  • Peter M. Clifton

    (Clinical and Health Sciences, University of South Australia, Adelaide, SA 5001, Australia)

Abstract

Magnesium (Mg) deficiency might be a catalyst in the process of endothelial dysfunction, an early event in the pathogenesis of atherosclerosis. The aim of this study was to determine the acute effect of an oral Mg supplement as compared to control on endothelial function assessed by flow-mediated dilatation (FMD). Nineteen participants (39 years, body mass index (BMI) 22.9 kg/m 2 ) completed this randomized cross-over study. Blood pressure (BP) and FMD were measured and blood samples were taken before participants drank 200 mL water, with or without an over the counter Mg supplement (450 mg and 300 mg for men and women). Measurements were repeated at 60 and 120 min. There was a statistically significant two-way interaction between treatment and time on serum Mg ( p = 0.037). A difference of −0.085 mm in FMD was observed 60-min post drink in the control group, as compared to baseline FMD, and no difference was observed in the supplement group as compared to baseline. Despite the non-significant interaction between treatment and time on FMD, once adjusted for baseline, the difference seen in the control group and the lack of change in the supplement group at 60 min post-drink suggests that Mg might attenuate the reduction in FMD post-prandially.

Suggested Citation

  • Caitríona Murphy & Jennifer Byrne & Jennifer B. Keogh & Michelle L. Headland & Peter M. Clifton, 2021. "The Acute Effect of Magnesium Supplementation on Endothelial Function: A Randomized Cross-Over Pilot Study," IJERPH, MDPI, vol. 18(10), pages 1-9, May.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:10:p:5303-:d:555794
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    References listed on IDEAS

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    1. Xinhua Qu & Fangchun Jin & Yongqiang Hao & Huiwu Li & Tingting Tang & Hao Wang & Weili Yan & Kerong Dai, 2013. "Magnesium and the Risk of Cardiovascular Events: A Meta-Analysis of Prospective Cohort Studies," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-13, March.
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