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Effect of Periodontitis and Scaling and Root Planing on Risk of Pharyngeal Cancer: A Nested Case—Control Study

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  • Ping-Ju Chen

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Dentistry, Changhua Christian Hospital, Changhua 500, Taiwan
    These authors contributed equally to the work.)

  • Yin-Yang Chen

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Surgery, Chung Shan Medical University Hospital, Taichung 402, Taiwan
    These authors contributed equally to the work.)

  • Chiao-Wen Lin

    (Institute of Oral Sciences, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Dentistry, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Ying-Tung Yeh

    (Department of Dentistry, Chung Shan Medical University Hospital, Taichung 402, Taiwan
    Graduate School of Dentistry, School of Dentistry, Chung Shan Medical University, Taichung 402, Taiwan)

  • Han-Wei Yeh

    (School of Medicine, Chang Gung University, Taoyuan City 333, Taiwan)

  • Jing-Yang Huang

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Shun-Fa Yang

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Chao-Bin Yeh

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Emergency Medicine, School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

Abstract

This study investigated the association between periodontitis and the risk of pharyngeal cancer in Taiwan. For this population-based nested case–control study using the Longitudinal Health Insurance Database derived from Taiwan’s National Health Insurance Research Database, we identified patients ( n = 1292) who were newly diagnosed with pharyngeal cancer between 2005 and 2013 and exactly paired them with propensity score matched control subjects ( n = 2584). Periodontitis and scaling and root planing (SRP) were identified before the index date. Pharyngeal cancer was subdivided into 3 subgroups on the basis of anatomic location: nasopharyngeal cancer, oropharyngeal cancer, and hypopharyngeal cancer. A multiple conditional logistic regression model was applied to analyze the adjusted odds ratio (aOR). Periodontitis was associated with an increased risk of pharyngeal cancer (aOR, 1.57; 95% confidence interval (CI), 1.17 to 2.10), especially oropharyngeal cancer (aOR, 2.22; 95% CI, 1.07 to 4.60). We found a decreased risk of pharyngeal cancer in patients who had undergone SRP (aOR, 0.77; 95% CI, 0.61 to 0.96). In conclusion, this study showed that periodontitis was associated with an increased risk of pharyngeal cancer and SRP exerted a protective effect against pharyngeal cancer. Our results suggest that treating periodontitis and performing SRP, which are modifiable factors in oral health, in clinical practice may provide an opportunity to decrease the disease burden of pharyngeal cancer in Taiwan.

Suggested Citation

  • Ping-Ju Chen & Yin-Yang Chen & Chiao-Wen Lin & Ying-Tung Yeh & Han-Wei Yeh & Jing-Yang Huang & Shun-Fa Yang & Chao-Bin Yeh, 2020. "Effect of Periodontitis and Scaling and Root Planing on Risk of Pharyngeal Cancer: A Nested Case—Control Study," IJERPH, MDPI, vol. 18(1), pages 1-12, December.
  • Handle: RePEc:gam:jijerp:v:18:y:2020:i:1:p:8-:d:466362
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    References listed on IDEAS

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    1. Stefano Corbella & Paolo Veronesi & Viviana Galimberti & Roberto Weinstein & Massimo Del Fabbro & Luca Francetti, 2018. "Is periodontitis a risk indicator for cancer? A meta-analysis," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-15, April.
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