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Association between Adherence with Recommended Antenatal Care in Low-Risk, Uncomplicated Pregnancy, and Maternal and Neonatal Adverse Outcomes: Evidence from Italy

Author

Listed:
  • Giovanni Corrao

    (National Centre for Healthcare Research and Pharmacoepidemiology, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, 20126 Milan, Italy
    Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, 20126 Milan, Italy)

  • Anna Cantarutti

    (National Centre for Healthcare Research and Pharmacoepidemiology, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, 20126 Milan, Italy
    Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, 20126 Milan, Italy)

  • Anna Locatelli

    (Department of Obstetrics and Gynecology, ASST Vimercate, Vittorio Emanuele III Hospital, University of Milano-Bicocca, Monza-Brianza, 20126 Milan, Italy)

  • Gloria Porcu

    (National Centre for Healthcare Research and Pharmacoepidemiology, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, 20126 Milan, Italy
    Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, 20126 Milan, Italy)

  • Luca Merlino

    (Welfare Department, Epidemiologic Observatory, Lombardy Region, 20121 Milan, Italy)

  • Simona Carbone

    (Department of Health Planning, Italian Health Ministry, 5–00144 Rome, Italy)

  • Flavia Carle

    (National Centre for Healthcare Research and Pharmacoepidemiology, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, 20126 Milan, Italy
    Center of Epidemiology and Biostatistics, Polytechnic University of Marche, 60121 Ancona, Italy)

  • Rinaldo Zanini

    (Woman and Child Health Department, Azienda Ospedaliera della Provincia di Lecco, 23900 Lecco, Italy)

Abstract

Antenatal care (ANC) aims of monitoring wellbeing of mother and foetus during pregnancy. We validate a set of indicators aimed of measuring the quality of ANC of women on low-risk, uncomplicated pregnancy through their relationship with maternal and neonatal outcomes. We conducted a population-based cohort study including 122,563 deliveries that occurred between 2015 and 2017 in the Lombardy Region, Italy. Promptness and appropriateness of number and timing of gynaecological visits, ultrasounds and laboratory tests were evaluated. We assessed several maternal and neonatal outcomes. Log-binomial regression models were used to estimate prevalence ratio (PR), and corresponding 95% confidence interval (95% CI), for the exposure→outcome association. Compared with women who adhered with recommendations, those who were no adherent had a significant higher prevalence of maternal intensive care units admission (PR: 3.1, 95%CI: 1.2–7.9; and 2.7, 1.1–7.0 respectively for promptness of gynaecological visits, and appropriateness of ultrasound examinations), low Apgar score (1.6, 1.1–1.2; 1.9, 1.3–2.7; and 2.1, 1.5–2.8 respectively for appropriateness and promptness of gynaecological visits, and appropriateness of ultrasound examinations), and low birth weight (1.8, 1.5–2.3 for appropriateness of laboratory test examinations). Benefits for mothers and newborn are expected from improving adherence to guidelines-driven recommendations regarding antenatal care even for low-risk, uncomplicated pregnancies.

Suggested Citation

  • Giovanni Corrao & Anna Cantarutti & Anna Locatelli & Gloria Porcu & Luca Merlino & Simona Carbone & Flavia Carle & Rinaldo Zanini, 2020. "Association between Adherence with Recommended Antenatal Care in Low-Risk, Uncomplicated Pregnancy, and Maternal and Neonatal Adverse Outcomes: Evidence from Italy," IJERPH, MDPI, vol. 18(1), pages 1-14, December.
    • Handle: RePEc:gam:jijerp:v:18:y:2020:i:1:p:173-:d:469705
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    References listed on IDEAS

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    1. Giovanni Corrao & Federico Rea & Matteo Franchi & Benedetta Beccalli & Anna Locatelli & Anna Cantarutti, 2020. "Warning of Immortal Time Bias When Studying Drug Safety in Pregnancy: Application to Late Use of Antibiotics and Preterm Delivery," IJERPH, MDPI, vol. 17(18), pages 1-11, September.
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