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Distal Symmetric and Cardiovascular Autonomic Neuropathies in Brazilian Individuals with Type 2 Diabetes Followed in a Primary Health Care Unit: A Cross-Sectional Study

Author

Listed:
  • Mozania Reis de Matos

    (Programa de Pos-Graduaçao em Medicina, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 235, 2° subsolo, Pos-graduação, Sao Paulo 01504-001, Brazil
    Unidade Basica de Saude Dra. Ilza Weltman Hutzler. Rua Coronel Walfrido de Carvalho, Sao Paulo 02472-180, Brazil
    These authors contributed equally to the research.)

  • Daniele Pereira Santos-Bezerra

    (Laboratorio de Carboidratos e Radioimunoensaio (LIM-18), Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de Sao Paulo. Avenida Dr. Arnaldo, 455, Sala 3321, Sao Paulo 01246-903, Brazil
    These authors contributed equally to the research.)

  • Cristiane das Graças Dias Cavalcante

    (Unidade Basica de Saude Dra. Ilza Weltman Hutzler. Rua Coronel Walfrido de Carvalho, Sao Paulo 02472-180, Brazil)

  • Jacira Xavier de Carvalho

    (Unidade Basica de Saude Dra. Ilza Weltman Hutzler. Rua Coronel Walfrido de Carvalho, Sao Paulo 02472-180, Brazil)

  • Juliana Leite

    (Programa de Pos-Graduaçao em Medicina, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 235, 2° subsolo, Pos-graduação, Sao Paulo 01504-001, Brazil)

  • Jose Antonio Januario Neves

    (Programa de Pos-Graduaçao em Medicina, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 235, 2° subsolo, Pos-graduação, Sao Paulo 01504-001, Brazil)

  • Sharon Nina Admoni

    (Laboratorio de Carboidratos e Radioimunoensaio (LIM-18), Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de Sao Paulo. Avenida Dr. Arnaldo, 455, Sala 3321, Sao Paulo 01246-903, Brazil)

  • Marisa Passarelli

    (Programa de Pos-Graduaçao em Medicina, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 235, 2° subsolo, Pos-graduação, Sao Paulo 01504-001, Brazil
    Laboratorio de Lipides (LIM-10), Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de Sao Paulo, Avenida Dr. Arnaldo, 455, Sala 3305, Sao Paulo 01246-903, Brazil)

  • Maria Candida Parisi

    (Divisao de Endocrinologia, Departamento de Clinica Medica, Faculdade de Medicina da Universidade Estadual de Campinas (UNICAMP), Rua Tessalia Vieira de Camargo, 126 – Cidade Universitaria, Campinas 13083-887, Brazil)

  • Maria Lucia Correa-Giannella

    (Programa de Pos-Graduaçao em Medicina, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 235, 2° subsolo, Pos-graduação, Sao Paulo 01504-001, Brazil
    Laboratorio de Carboidratos e Radioimunoensaio (LIM-18), Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de Sao Paulo. Avenida Dr. Arnaldo, 455, Sala 3321, Sao Paulo 01246-903, Brazil)

Abstract

The paucity of epidemiological data regarding diabetes complications in Brazil motivated us to evaluate the prevalence rates of distal symmetric polyneuropathy (DSP) and of cardiovascular autonomic neuropathy (CAN) in individuals with type 2 diabetes (T2D) followed in a primary care unit. A total of 551 individuals (59.3% women, 65 years old; diabetes duration of 10 years; HbA1c of 7.2%, medians) were included in this cross-sectional study. DSP was diagnosed by sum of the Neuropathy Symptoms Score (NSS) and Modified Neuropathy Disability Score (NDS) and by the Semmes–Weinstein monofilament. CAN was diagnosed by cardiovascular autonomic reflex tests combined with spectral analysis of heart rate variability. The prevalence rates of DSP were 6.3% and 14.3%, as evaluated by the sum of NSS and NDS and by the Semmes–Weinstein monofilament, respectively. Those with DSP diagnosed by monofilament presented longer diabetes duration, worse glycemic control and a higher stature. The prevalence rates of incipient and definitive CAN were 12.5% and 10%, respectively. Individuals with definitive CAN presented a higher frequency of hypercholesterolemia and of arterial hypertension. The higher prevalence rate of DSP with the use of the monofilament suggests that it may be a more appropriate tool to diagnose DSP in the primary care setting in Brazil.

Suggested Citation

  • Mozania Reis de Matos & Daniele Pereira Santos-Bezerra & Cristiane das Graças Dias Cavalcante & Jacira Xavier de Carvalho & Juliana Leite & Jose Antonio Januario Neves & Sharon Nina Admoni & Marisa Pa, 2020. "Distal Symmetric and Cardiovascular Autonomic Neuropathies in Brazilian Individuals with Type 2 Diabetes Followed in a Primary Health Care Unit: A Cross-Sectional Study," IJERPH, MDPI, vol. 17(9), pages 1-9, May.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:9:p:3232-:d:354569
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