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Patterns of Comorbidity in Hepatocellular Carcinoma: A Network Perspective

Author

Listed:
  • Xiao-Min Mu

    (Department of Medical Informatics, School of Public Health, Jilin University, Changchun 130021, China)

  • Wei Wang

    (Department of Medical Informatics, School of Public Health, Jilin University, Changchun 130021, China)

  • Yu-Ying Jiang

    (Department of Medical Informatics, School of Public Health, Jilin University, Changchun 130021, China)

  • Jia Feng

    (Department of Medical Informatics, School of Public Health, Jilin University, Changchun 130021, China
    Cancer Systems Biology Center, Jilin University, Changchun 130033, China
    College of Computer Science and Technology, Jilin University, Changchun 130012, China)

Abstract

Hepatocellular carcinoma (HCC) is a common and fatal cancer. People with HCC report higher odds of comorbidity compared with people without HCC. To explore the association between HCC and medical comorbidity, we used routinely collected clinical data and applied a network perspective. In the network perspective, we used correlation analysis and community detection tests that described direct relationships among comorbidities. We collected 14,891 patients with HCC living in Jilin Province, China, between 2016 and 2018. Cirrhosis was the most common comorbidity of HCC. Hypertension and renal cysts were more common in male patients, while chronic viral hepatitis C, hypersplenism, hypoproteinemia, anemia and coronary heart disease were more common in female patients. The proportion of chronic diseases in comorbidities increased with age. The main comorbidity patterns of HCC were: HCC, cirrhosis, chronic viral hepatitis B, portal hypertension, ascites and other common complications of cirrhosis; HCC, hypertension, diabetes mellitus, coronary heart disease and cerebral infarction; and HCC, hypoproteinemia, electrolyte disorders, gastrointestinal hemorrhage and hemorrhagic anemia. Our findings provide comprehensive information on comorbidity patterns of HCC, which may be used for the prevention and management of liver cancer.

Suggested Citation

  • Xiao-Min Mu & Wei Wang & Yu-Ying Jiang & Jia Feng, 2020. "Patterns of Comorbidity in Hepatocellular Carcinoma: A Network Perspective," IJERPH, MDPI, vol. 17(9), pages 1-10, April.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:9:p:3108-:d:352037
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    Citations

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    Cited by:

    1. Xiao-Min Mu & Wei Wang & Fang-Yi Wu & Yu-Ying Jiang & Ling-ling Ma & Jia Feng, 2020. "Comorbidity in Older Patients Hospitalized with Cancer in Northeast China based on Hospital Discharge Data," IJERPH, MDPI, vol. 17(21), pages 1-12, October.
    2. David Hsiehchen & Muhammad S. Beg & Radhika Kainthla & Jay Lohrey & Syed M. Kazmi & Leticia Khosama & Mary Claire Maxwell & Heather Kline & Courtney Katz & Asim Hassan & Naoto Kubota & Ellen Siglinsky, 2024. "The phosphatidylserine targeting antibody bavituximab plus pembrolizumab in unresectable hepatocellular carcinoma: a phase 2 trial," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    3. Chiyoung Lee & Sijia Wei & Eleanor S. McConnell & Hideyo Tsumura & Tingzhong (Michelle) Xue & Wei Pan, 2024. "Comorbidity Patterns in Older Patients Undergoing Hip Fracture Surgery: A Comorbidity Network Analysis Study," Clinical Nursing Research, , vol. 33(1), pages 70-80, January.

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