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Promising Scaffold-Free Approaches in Translational Dentistry

Author

Listed:
  • Marco Tatullo

    (Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, 70122 Bari, Italy
    Marrelli Health, Tecnologica Research Institute, 88900 Crotone, Italy
    Department of Therapeutic Dentistry, Sechenov University Russia, Moscow 119146, Russia)

  • Benedetta Marrelli

    (Marrelli Health, Tecnologica Research Institute, 88900 Crotone, Italy)

  • Francesca Palmieri

    (Marrelli Health, Tecnologica Research Institute, 88900 Crotone, Italy)

  • Massimiliano Amantea

    (Marrelli Health, Tecnologica Research Institute, 88900 Crotone, Italy)

  • Manuel Nuzzolese

    (North Manchester General Hospital, Manchester M8 5RB, UK)

  • Rosa Valletta

    (Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples, 80131 Naples, Italy)

  • Barbara Zavan

    (Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy
    They are co-last authors.)

  • Danila De Vito

    (Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, 70122 Bari, Italy
    They are co-last authors.)

Abstract

Regenerative medicine has recently improved the principal therapies in several medical fields. In the past ten years, the continuous search for novel approaches to treat the most common dental pathologies has developed a new branch called regenerative dentistry. The main research fields of translational dentistry involve biomimetic materials, orally derived stem cells, and tissue engineering to populate scaffolds with autologous stem cells and bioactive growth factors. The scientific literature has reported two main research trends in regenerative dentistry: scaffold-based and scaffold-free approaches. This article aims to critically review the main biological properties of scaffold-free regenerative procedures in dentistry. The most impactful pros and cons of the exosomes, the leading role of hypoxia-based mesenchymal stem cells (MSCs), and the strategic use of heat shock proteins in regenerative dentistry will be highlighted and discussed in terms of the use of such tools in dental regeneration and repair.

Suggested Citation

  • Marco Tatullo & Benedetta Marrelli & Francesca Palmieri & Massimiliano Amantea & Manuel Nuzzolese & Rosa Valletta & Barbara Zavan & Danila De Vito, 2020. "Promising Scaffold-Free Approaches in Translational Dentistry," IJERPH, MDPI, vol. 17(9), pages 1-8, April.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:9:p:3001-:d:350572
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