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The Effect of Vitamin D 3 Supplementation on Hepcidin, Iron, and IL-6 Responses after a 100 km Ultra-Marathon

Author

Listed:
  • Katarzyna Kasprowicz

    (Department of Molecular Biology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland)

  • Wojciech Ratkowski

    (Department of Athletics, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland)

  • Wojciech Wołyniec

    (Department of Occupational, Metabolic and Internal Diseases, Medical University of Gdansk, 81-519 Gdynia, Poland)

  • Mariusz Kaczmarczyk

    (Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, 70-11 Szczecin, Poland)

  • Konrad Witek

    (Department of Biochemistry, Institute of Sport, National Research Institute, 01-982 Warsaw, Poland)

  • Piotr Żmijewski

    (Faculty of Physical Education, Jozef Piłsudski University of Physical Education in Warsaw, 01-813 Warsaw, Poland)

  • Marcin Renke

    (Department of Occupational, Metabolic and Internal Diseases, Medical University of Gdansk, 81-519 Gdynia, Poland)

  • Zbigniew Jastrzębski

    (Department of Physiology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland)

  • Thomas Rosemann

    (Institute of Primary Care, University of Zurich, 8091 Zurich, Switzerland)

  • Pantelis T. Nikolaidis

    (Exercise Physiology Laboratory, 18450 Nikaia, Greece)

  • Beat Knechtle

    (Institute of Primary Care, University of Zurich, 8091 Zurich, Switzerland
    Medbase St. Gallen Am Vadianplatz, 9001 St. Gallen, Switzerland)

Abstract

Deficiencies in iron and vitamin D are frequently observed in athletes. Therefore, we examined whether different baseline vitamin D 3 levels have any impact on post-exercise serum hepcidin, IL-6 and iron responses in ultra-marathon runners. In this randomized control trial, the subjects (20 male, amateur runners, mean age 40.75 ± 7.15 years) were divided into two groups: experimental (VD) and control (CON). The VD group received vitamin D 3 (10,000 UI/day) and the CON group received a placebo for two weeks before the run. Venous blood samples were collected on three occasions—before the run, after the 100 km ultra-marathon and 12 h after the run—to measure iron metabolism indicators, hepcidin, and IL-6 concentration. After two weeks of supplementation, the intervention group demonstrated a higher level of serum 25(OH)D than the CON group (27.82 ± 5.8 ng/mL vs. 20.41 ± 4.67 ng/mL; p < 0.05). There were no differences between the groups before and after the run in the circulating hepcidin and IL-6 levels. The decrease in iron concentration immediately after the 100-km ultra-marathon was smaller in the VD group than CON ( p < 0.05). These data show that various vitamin D 3 status can affect the post-exercise metabolism of serum iron.

Suggested Citation

  • Katarzyna Kasprowicz & Wojciech Ratkowski & Wojciech Wołyniec & Mariusz Kaczmarczyk & Konrad Witek & Piotr Żmijewski & Marcin Renke & Zbigniew Jastrzębski & Thomas Rosemann & Pantelis T. Nikolaidis & , 2020. "The Effect of Vitamin D 3 Supplementation on Hepcidin, Iron, and IL-6 Responses after a 100 km Ultra-Marathon," IJERPH, MDPI, vol. 17(8), pages 1-13, April.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:8:p:2962-:d:349955
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