IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i8p2825-d347832.html
   My bibliography  Save this article

Comorbidities and Outcome of Alcoholic and Non-Alcoholic Liver Cirrhosis in Taiwan: A Population-Based Study

Author

Listed:
  • Tzu-Wei Yang

    (School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Chi-Chih Wang

    (School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Ming-Chang Tsai

    (School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Yao-Tung Wang

    (School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Division of Pulmonary Medicine, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Ming-Hseng Tseng

    (Department of Medical Informatics, Chung Shan Medical University, Taichung 402, Taiwan
    Information Technology Office, Chung Shan Medical University Hospital, Taichung 402, Taiwan
    These authors contributed equally to this work.)

  • Chun-Che Lin

    (Department of Internal Medicine, China Medical University Hospital, Taichung 404, Taiwan
    School of Medicine, China Medical University, Taichung 404, Taiwan
    These authors contributed equally to this work.)

Abstract

The prognosis of different etiologies of liver cirrhosis (LC) is not well understood. Previous studies performed on alcoholic LC-dominated cohorts have demonstrated a few conflicting results. We aimed to compare the outcome and the effect of comorbidities on survival between alcoholic and non-alcoholic LC in a viral hepatitis-dominated LC cohort. We identified newly diagnosed alcoholic and non-alcoholic LC patients, aged ≥40 years old, between 2006 and 2011, by using the Longitudinal Health Insurance Database. The hazard ratios (HRs) were calculated using the Cox proportional hazards model and the Kaplan–Meier method. A total of 472 alcoholic LC and 4313 non-alcoholic LC patients were identified in our study cohort. We found that alcoholic LC patients were predominantly male (94.7% of alcoholic LC and 62.6% of non-alcoholic LC patients were male) and younger (78.8% of alcoholic LC and 37.4% of non-alcoholic LC patients were less than 60 years old) compared with non-alcoholic LC patients. Non-alcoholic LC patients had a higher rate of concomitant comorbidities than alcoholic LC patients (79.6% vs. 68.6%, p < 0.001). LC patients with chronic kidney disease demonstrated the highest adjusted HRs of 2.762 in alcoholic LC and 1.751 in non-alcoholic LC (all p < 0.001). In contrast, LC patients with hypertension and hyperlipidemia had a decreased risk of mortality. The six-year survival rates showed no difference between both study groups ( p = 0.312). In conclusion, alcoholic LC patients were younger and had lower rates of concomitant comorbidities compared with non-alcoholic LC patients. However, all-cause mortality was not different between alcoholic and non-alcoholic LC patients.

Suggested Citation

  • Tzu-Wei Yang & Chi-Chih Wang & Ming-Chang Tsai & Yao-Tung Wang & Ming-Hseng Tseng & Chun-Che Lin, 2020. "Comorbidities and Outcome of Alcoholic and Non-Alcoholic Liver Cirrhosis in Taiwan: A Population-Based Study," IJERPH, MDPI, vol. 17(8), pages 1-10, April.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:8:p:2825-:d:347832
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/8/2825/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/17/8/2825/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:8:p:2825-:d:347832. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.