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Modification of PARP4 , XRCC3 , and RAD51 Gene Polymorphisms on the Relation between Bisphenol A Exposure and Liver Abnormality

Author

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  • Jin Hee Kim

    (Department of Integrative Bioscience & Biotechnology, Sejong University, 209 Neungdong-ro, Gwangjin-gu, Seoul 05006, Korea)

  • Yun-Chul Hong

    (Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 03080, Korea
    Institute of Environmental Medicine, Seoul National University Medical Research Center, 28 Yongon-dong, Chongno-gu, Seoul 03080, Korea)

Abstract

Repair genes may play critical roles in the relationships between environmental exposure and health outcomes. However, no evidence is available about the effect of repair gene polymorphisms on the relationship between bisphenol A (BPA) exposure and liver abnormality. Therefore, we evaluated the effect of nine genotyped polymorphisms in three repair genes, poly(ADP-ribose) polymerase family member 4 ( PARP4 ), X-ray repair cross complementing 3 ( XRCC3 ), and RAD51 recombinase ( RAD51 ), on the relationship between BPA exposure and liver abnormality using repeated measures data for an elderly population. A significant association between BPA levels and liver abnormality was found only in elders with the PARP4 G-C-G haplotype, XRCC3 G-A-G haplotype, or RAD51 T-A-A haplotype (odds ratio (OR) = 2.16 and p = 0.0014 for PARP4 ; OR = 1.57 and p = 0.0249 for XRCC3 ; OR = 1.43 and p = 0.0422 for RAD51 ). Particularly, PARP4 and XRCC3 showed significant interactions with BPA exposure in relation to liver abnormality ( p < 0.05 for both genes). These results indicate that PARP4 , XRCC3 , and RAD51 gene polymorphisms have modification effects on the relationship between BPA exposure and liver abnormality.

Suggested Citation

  • Jin Hee Kim & Yun-Chul Hong, 2020. "Modification of PARP4 , XRCC3 , and RAD51 Gene Polymorphisms on the Relation between Bisphenol A Exposure and Liver Abnormality," IJERPH, MDPI, vol. 17(8), pages 1-19, April.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:8:p:2794-:d:347212
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    References listed on IDEAS

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    1. Kembra L. Howdeshell & Andrew K. Hotchkiss & Kristina A. Thayer & John G. Vandenbergh & Frederick S. vom Saal, 1999. "Exposure to bisphenol A advances puberty," Nature, Nature, vol. 401(6755), pages 763-764, October.
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    Cited by:

    1. Jin Hee Kim & Seungho Lee & Yun-Chul Hong, 2022. "Modification Effect of PARP4 and ERCC1 Gene Polymorphisms on the Relationship between Particulate Matter Exposure and Fasting Glucose Level," IJERPH, MDPI, vol. 19(10), pages 1-13, May.

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