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Increased Risk of Polycystic Ovary Syndrome and It’s Comorbidities in Women with Autoimmune Thyroid Disease

Author

Listed:
  • Chun-Wei Ho

    (Intelligent Diabetes Metabolism and Exercise Center, China Medical University Hospital, Taichung 40447, Taiwan
    Chun-Wei Ho and Hsin-Hung Chen are equally contributed to this article.)

  • Hsin-Hung Chen

    (Intelligent Diabetes Metabolism and Exercise Center, China Medical University Hospital, Taichung 40447, Taiwan
    School of Medicine, Institute of Medicine and Public Health, Chung Shan Medical University, Taichung 40201, Taiwan
    Chun-Wei Ho and Hsin-Hung Chen are equally contributed to this article.)

  • Ming-Chia Hsieh

    (Intelligent Diabetes Metabolism and Exercise Center, China Medical University Hospital, Taichung 40447, Taiwan
    Division of Clinical Nutrition, China Medical University Hospital, Taichung 40447, Taiwan
    Graduate Institute of Integrative Medicine, China Medical University, Taichung 40447, Taiwan)

  • Ching-Chu Chen

    (Division of Endocrinology and Metabolism, Department of Internal Medicine, China Medical University Hospital, Taichung 40447, Taiwan
    School of Chinese Medicine, China Medical University, Taichung 40447, Taiwan)

  • Sheng-Pang Hsu

    (Division of Endocrinology and Metabolism, Department of Internal Medicine, China Medical University Hospital, Taichung 40447, Taiwan)

  • Hei-Tung Yip

    (Management Office for Health Data, China Medical University Hospital, Taichung 40447, Taiwan
    College of Medicine, China Medical University, Taichung 40447, Taiwan)

  • Chia-Hung Kao

    (Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, Taichung 40447, Taiwan
    Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung 40447, Taiwan
    Department of Bioinformatics and Medical Engineering, Asia University, Taichung 40447, Taiwan
    Center of Augmented Intelligence in Healthcare, China Medical University Hospital, Taichung 40447, Taiwan)

Abstract

Objective: To investigate the prevalence of polycystic ovary syndrome (PCOS) and its comorbidities in patients with autoimmune thyroid disease (AITD). Population: In this cohort study, patients newly diagnosed as having Hashimoto thyroiditis (HT) or Grave disease (GD) were recruited into the AITD group. Method: The logistic regression model was used to investigate the association between exposure, endpoint, later diseases and treatment. Main Outcome Measures: We assessed the cumulative incidence using the Kaplan–Meier method and verified the difference by the log-rank test. Results: The AITD group included 3599 GD patients and 1332 HT patients. PCOS risk in patients with AITD was higher than that in the control group (adjusted hazard ratio = 1.39; 95% confidence interval = 1.07–1.71). In patients with both AITD and PCOS, the odds ratios of diabetes, hyperlipidemia and coronary artery disease were 2.48, 2.05 and 2.63, respectively. Conclusions: The risks of PCOS and its comorbidities such as diabetes, dyslipidemia and cardiac artery disease are high in patients with AITD in Taiwan.

Suggested Citation

  • Chun-Wei Ho & Hsin-Hung Chen & Ming-Chia Hsieh & Ching-Chu Chen & Sheng-Pang Hsu & Hei-Tung Yip & Chia-Hung Kao, 2020. "Increased Risk of Polycystic Ovary Syndrome and It’s Comorbidities in Women with Autoimmune Thyroid Disease," IJERPH, MDPI, vol. 17(7), pages 1-8, April.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:7:p:2422-:d:340568
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