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Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds

Author

Listed:
  • Javad Sharifi-Rad

    (Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol 61615-585, Iran)

  • Célia F. Rodrigues

    (LEPABE—Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal)

  • Farukh Sharopov

    (Department of Pharmaceutical Technology, Avicenna Tajik State Medical University, Rudaki 139, 734003 Dushanbe, Tajikistan)

  • Anca Oana Docea

    (Department of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania)

  • Aslı Can Karaca

    (Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul 34469, Turkey)

  • Mehdi Sharifi-Rad

    (Department of Medical Parasitology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman 7616913555, Iran)

  • Derya Kahveci Karıncaoglu

    (Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul 34469, Turkey)

  • Gözde Gülseren

    (Department of Food Engineering, Chemical and Metallurgical Faculty, Istanbul Technical University, Maslak Istanbul 34469, Turkey)

  • Ezgi Şenol

    (Department of Food Engineering, Chemical and Metallurgical Faculty, Istanbul Technical University, Maslak Istanbul 34469, Turkey)

  • Evren Demircan

    (Department of Food Engineering, Chemical and Metallurgical Faculty, Istanbul Technical University, Maslak Istanbul 34469, Turkey)

  • Yasaman Taheri

    (Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1991953381, Iran)

  • Hafiz Ansar Rasul Suleria

    (Department of Agriculture and Food Systems, The University of Melbourne, Melbourne 3010, Australia)

  • Beraat Özçelik

    (Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul 34469, Turkey
    Bioactive Research & Innovation Food Manufac. Indust. Trade Ltd., Katar Street, Teknokent ARI-3, B110, Sarıyer, Istanbul 34467, Turkey)

  • Kadriye Nur Kasapoğlu

    (Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul 34469, Turkey)

  • Mine Gültekin-Özgüven

    (Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul 34469, Turkey)

  • Ceren Daşkaya-Dikmen

    (Pladis TR R&D Department, Kısıklı mah., Ferah cad. Üsküdar İstanbul 34692, Turkey)

  • William C. Cho

    (Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Hong Kong, China)

  • Natália Martins

    (Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal
    Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal)

  • Daniela Calina

    (Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania)

Abstract

Heart and blood vessels disorders comprise one of the main causes of death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around the world in a traditional way. Dietary, natural bioactive compounds, as well as healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical and clinical studies reported that consumption of plant-food bioactive derivatives including polyphenolic compounds, peptides, oligosaccharides, vitamins, unsaturated fatty acids possess protective effects on cardiovascular diseases. This review aims to summarize the cardiovascular risk factors, pre-clinical studies and clinical trials related to cardioprotective properties of the plant-food-derived bioactive compounds. Molecular mechanisms by the natural bioactive compounds exert their cardiovascular protective properties have also been highlighted.

Suggested Citation

  • Javad Sharifi-Rad & Célia F. Rodrigues & Farukh Sharopov & Anca Oana Docea & Aslı Can Karaca & Mehdi Sharifi-Rad & Derya Kahveci Karıncaoglu & Gözde Gülseren & Ezgi Şenol & Evren Demircan & Yasaman Ta, 2020. "Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds," IJERPH, MDPI, vol. 17(7), pages 1-31, March.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:7:p:2326-:d:338918
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    Cited by:

    1. Domenico Di Raimondo & Gaia Musiari & Giuliana Rizzo & Edoardo Pirera & Salvatore Santo Signorelli, 2022. "New Insights in Prevention and Treatment of Cardiovascular Disease," IJERPH, MDPI, vol. 19(4), pages 1-7, February.

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