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Environmental Monitoring of PAHs Exposure, Biomarkers and Vital Status in Coke Oven Workers

Author

Listed:
  • Luigi Vimercati

    (Interdisciplinary Department of Medicine, Occupational Medicine “B. Ramazzini”, University of Bari Medical School, 11 G. Cesare Square, 70124 Bari, Italy)

  • Lucia Bisceglia

    (Strategic Regional Health and Social Agency of Puglia (AReS Puglia), 52 G. Gentile Street, 70126 Bari, Italy)

  • Domenica Cavone

    (Interdisciplinary Department of Medicine, Occupational Medicine “B. Ramazzini”, University of Bari Medical School, 11 G. Cesare Square, 70124 Bari, Italy)

  • Antonio Caputi

    (Interdisciplinary Department of Medicine, Occupational Medicine “B. Ramazzini”, University of Bari Medical School, 11 G. Cesare Square, 70124 Bari, Italy)

  • Luigi De Maria

    (Interdisciplinary Department of Medicine, Occupational Medicine “B. Ramazzini”, University of Bari Medical School, 11 G. Cesare Square, 70124 Bari, Italy)

  • Maria Celeste Delfino

    (Interdisciplinary Department of Medicine, Occupational Medicine “B. Ramazzini”, University of Bari Medical School, 11 G. Cesare Square, 70124 Bari, Italy)

  • Vincenzo Corrado

    (Interdisciplinary Department of Medicine, Occupational Medicine “B. Ramazzini”, University of Bari Medical School, 11 G. Cesare Square, 70124 Bari, Italy)

  • Giovanni Maria Ferri

    (Interdisciplinary Department of Medicine, Occupational Medicine “B. Ramazzini”, University of Bari Medical School, 11 G. Cesare Square, 70124 Bari, Italy)

Abstract

A follow-up study of a cohort of workers from a coke plant compared with a control group from the same industrial area was conducted in 2019. The recruitment and environmental and biomarker measurements were performed during 1993/1994. The environmental concentrations of polycyclic aromatic hydrocarbons (PAH), B(a)P, pyrene and nitro-PAH were measured. Personal data were collected via an individual semi-structured questionnaire by a trained physician. All biomarkers were measured after a specific blood drawing for every test. Significant risks (ORs) were observed for nitro-PAH ( ≥ 0.12 µg/m 3 ) [OR = 7.96 (1.01–62.82)], urinary 1-hydroxypyrene (1-OHpy) (≥0.99 µmoles/moles of creatinine) [OR = 11.71 (1.47–92.90)], PAH DNA adducts (P 32 ) (≥2.69 adducts/10 8 nucleotides) [OR = 5.46 (1.17–25.58)], total nitro-PAH hemoglobin adducts (≥161.68 fg/µg of Hb) [OR = 5.92 (1.26–27.86)], sister chromatid exchange (SCE) with TCR (≥377.84 SCE/cell chromosomes) [OR = 13.06 (3.95–93.10)], sister chromatid exchange with T (≥394.72 total SCE) [OR = 13.06 (3.95–93.10)], and sister chromatid exchange with X (≥8.19 mean SCE) [OR = 13.06 (3.95–93.10)]. Significant risk of death for all causes and chromosomal aberrations (48 h) (OR = 7.19 [1.19–43.44]) or micronuclei in culture at 48 h (OR = 3.86 [1.04–14.38]) were also found.

Suggested Citation

  • Luigi Vimercati & Lucia Bisceglia & Domenica Cavone & Antonio Caputi & Luigi De Maria & Maria Celeste Delfino & Vincenzo Corrado & Giovanni Maria Ferri, 2020. "Environmental Monitoring of PAHs Exposure, Biomarkers and Vital Status in Coke Oven Workers," IJERPH, MDPI, vol. 17(7), pages 1-33, March.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:7:p:2199-:d:336967
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