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New Approach Methods to Evaluate Health Risks of Air Pollutants: Critical Design Considerations for In Vitro Exposure Testing

Author

Listed:
  • Jose Zavala

    (MedTec Biolab, Inc., Hillsborough, NC 27278, USA)

  • Anastasia N. Freedman

    (Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA)

  • John T. Szilagyi

    (Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA)

  • Ilona Jaspers

    (Department of Pediatrics, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Center for Environmental Medicine, Asthma, and Lung Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Curriculum in Toxicology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    The Institute for Environmental Health Solutions, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA)

  • John F. Wambaugh

    (Center for Computational Toxicology and Exposure, Office of Research and Development, United States Environmental Protection Agency, Durham, NC 27709, USA)

  • Mark Higuchi

    (Center for Public Health and Environmental Assessment, Office of Research and Development, United States Environmental Protection Agency, Durham, NC 27709, USA)

  • Julia E. Rager

    (Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Curriculum in Toxicology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    The Institute for Environmental Health Solutions, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA)

Abstract

Air pollution consists of highly variable and complex mixtures recognized as major contributors to morbidity and mortality worldwide. The vast number of chemicals, coupled with limitations surrounding epidemiological and animal studies, has necessitated the development of new approach methods (NAMs) to evaluate air pollution toxicity. These alternative approaches include in vitro (cell-based) models, wherein toxicity of test atmospheres can be evaluated with increased efficiency compared to in vivo studies. In vitro exposure systems have recently been developed with the goal of evaluating air pollutant-induced toxicity; though the specific design parameters implemented in these NAMs-based studies remain in flux. This review aims to outline important design parameters to consider when using in vitro methods to evaluate air pollutant toxicity, with the goal of providing increased accuracy, reproducibility, and effectiveness when incorporating in vitro data into human health evaluations. This review is unique in that experimental considerations and lessons learned are provided, as gathered from first-hand experience developing and testing in vitro models coupled to exposure systems. Reviewed design aspects include cell models, cell exposure conditions, exposure chambers, and toxicity endpoints. Strategies are also discussed to incorporate in vitro findings into the context of in vivo toxicity and overall risk assessment.

Suggested Citation

  • Jose Zavala & Anastasia N. Freedman & John T. Szilagyi & Ilona Jaspers & John F. Wambaugh & Mark Higuchi & Julia E. Rager, 2020. "New Approach Methods to Evaluate Health Risks of Air Pollutants: Critical Design Considerations for In Vitro Exposure Testing," IJERPH, MDPI, vol. 17(6), pages 1-28, March.
  • Handle: RePEc:gam:jijerp:v:17:y:2020:i:6:p:2124-:d:335813
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    References listed on IDEAS

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    1. Susan L. Cutter & Bryan J. Boruff & W. Lynn Shirley, 2003. "Social Vulnerability to Environmental Hazards," Social Science Quarterly, Southwestern Social Science Association, vol. 84(2), pages 242-261, June.
    2. Elisabeth Øya & Rune Becher & Leni Ekeren & Anani K.J. Afanou & Johan Øvrevik & Jørn A. Holme, 2019. "Pro-Inflammatory Responses in Human Bronchial Epithelial Cells Induced by Spores and Hyphal Fragments of Common Damp Indoor Molds," IJERPH, MDPI, vol. 16(6), pages 1-16, March.
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    1. Chao Jin & Xiaodan Li & Teng Xu & Juntong Dong & Zhenlong Geng & Jia Liu & Chenyun Ding & Jingjing Hu & Ahmed El ALAOUI & Qing Zhao & Haifeng Liu, 2023. "Zero-Carbon and Carbon-Neutral Fuels: A Review of Combustion Products and Cytotoxicity," Energies, MDPI, vol. 16(18), pages 1-29, September.

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