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Less Favorable Lipid Profile and Higher Prevalence of Thyroid Antibodies in Women of Reproductive Age with High-Normal TSH—Retrospective Study

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  • Małgorzata Karbownik-Lewińska

    (Department of Oncological Endocrinology, Medical University of Lodz, 90-752 Lodz, Poland
    Polish Mother’s Memorial Hospital—Research Institute, 93-338 Lodz, Poland)

  • Jan Stępniak

    (Department of Oncological Endocrinology, Medical University of Lodz, 90-752 Lodz, Poland)

  • Anna Żurawska

    (Department of Oncological Endocrinology, Medical University of Lodz, 90-752 Lodz, Poland)

  • Andrzej Lewiński

    (Polish Mother’s Memorial Hospital—Research Institute, 93-338 Lodz, Poland
    Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, 93-338 Lodz, Poland)

Abstract

High-normal TSH can be associated with metabolic abnormalities and infertility. Aims of this study are to analyze retrospectively if routinely measured blood laboratory and anthropometric parameters differ between women of reproductive age with TSH < 2.5 mIU/L and with TSH ≥ 2.5 mIU/L. Retrospective analysis was performed in 466 female inpatients, aged 13–51, hospitalized in an endocrine department. The group of 280 patients with normal thyroid tests (TSH 0.27-4.2 mIU/L; normal FT3 and FT4) was selected and it was divided into two subgroups, i.e., with TSH < 2.5 mIU/L and TSH ≥ 2.5 mIU/L (n = 66; 23.6%). After excluding patients on L-thyroxine treatment (n = 240), those with TSH ≥ 2.5 mIU/L constituted 22.92% (n = 55). In the group of 280 patients with normal thyroid tests, an abnormally high concentration of triglycerides and an abnormally low HDLC/cholesterol ratio occurred more frequently in women with TSH ≥ 2.5 mIU/L than those with TSH < 2.5 mIU/L (17% vs. 7%, p = 0.017; 14% vs. 5%, p = 0.015, respectively). Increased concentration of thyroid antibodies, i.e., TPOAb, occurred more frequently in patients with TSH ≥ 2.5 mIU/L than those with TSH < 2.5 mIU/L (27% vs. 9%, p = 0.001). The same differences were found in the group of 240 patients after excluding those on L-thyroxine treatment. Blood lymphocyte concentration was the only independent linear parameter associated with TSH ≥ 2.5 mIU/L (OR = 1.551, p = 0.024) but only in the group of 280 patients with normal thyroid tests. TSH concentration correlated positively with blood lymphocyte (r = 0.129, p = 0.031) and TPOAb (r = 0.177, p = 0.005) concentrations but only in the group of 280 patients with normal thyroid tests. Less favorable lipid profiles and a higher prevalence of thyroid antibodies in women of reproductive age with high-normal TSH suggests that L-thyroxine treatment should be considered in such patients. The significance of a positive association between high-normal TSH and blood lymphocytes requires further evaluation.

Suggested Citation

  • Małgorzata Karbownik-Lewińska & Jan Stępniak & Anna Żurawska & Andrzej Lewiński, 2020. "Less Favorable Lipid Profile and Higher Prevalence of Thyroid Antibodies in Women of Reproductive Age with High-Normal TSH—Retrospective Study," IJERPH, MDPI, vol. 17(6), pages 1-11, March.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:6:p:2122-:d:335757
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    References listed on IDEAS

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    1. Daniela Calina & Anca Oana Docea & Kirill Sergeyevich Golokhvast & Stavros Sifakis & Aristides Tsatsakis & Antonis Makrigiannakis, 2019. "Management of Endocrinopathies in Pregnancy: A Review of Current Evidence," IJERPH, MDPI, vol. 16(5), pages 1-25, March.
    2. Weimin Xu & Liangliang Huo & Zexin Chen & Yangmei Huang & Xingyi Jin & Jing Deng & Sujuan Zhu & Yunxian Yu, 2017. "The Relationship of TPOAb and TGAb with Risk of Thyroid Nodules: A Large Epidemiological Study," IJERPH, MDPI, vol. 14(7), pages 1-11, July.
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