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Atopic Disease and Anemia in Korean Patients: Cross-Sectional Study with Propensity Score Analysis

Author

Listed:
  • Kiyon Rhew

    (College of Pharmacy, Seoul National University, Seoul 08826, Korea
    College of Pharmacy, Dongduk Women’s University, Seoul 08826, Korea)

  • Joshua D Brown

    (Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA)

  • Jung Mi Oh

    (College of Pharmacy, Seoul National University, Seoul 08826, Korea
    Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea)

Abstract

Atopic disease is associated with chronic inflammation, and anemia has been reported in patients with inflammatory disorders such as rheumatoid arthritis, chronic obstructive pulmonary disease, and irritable bowel disease. The objective of this study was to determine whether atopic disease is associated with an increased risk of anemia. A cross-sectional study with propensity score weighting was conducted using a health insurance review agency claims dataset comprised of randomized patients who used the Korean national health system at least once in 2016. The association between atopic disease (asthma, atopic dermatitis, allergic rhinitis) and anemia (iron deficiency anemia (IDA) and/or anemia of inflammation (AI)) was examined. A total of 1,468,033 patients were included in this study. The IDA/AI prevalence was 3.1% (45,681 patients). After propensity score weighting, there were 46,958 and 45,681 patients in the non-anemic and anemic groups, respectively. The prevalence of IDA/AI in patients with atopic dermatitis, allergic rhinitis, or asthma had an odds ratio (OR) of 1.40 (95% confidence interval (CI), 1.33–1.48; p < 0.001), 1.17 (95% CI, 1.14–1.21; p < 0.001), and 1.32 (95% CI, 1.28–1.36; p < 0.001), respectively. In addition, the prevalence of IDA increased with higher numbers of atopic diseases. In conclusion, the prevalence of IDA/AI was higher in patients with atopic disease, even after adjusting for demographic characteristics and other risk factors. Further study is needed to distinguish between IDA and AI and to enhance understanding of the etiology of anemia in patients with inflammatory conditions.

Suggested Citation

  • Kiyon Rhew & Joshua D Brown & Jung Mi Oh, 2020. "Atopic Disease and Anemia in Korean Patients: Cross-Sectional Study with Propensity Score Analysis," IJERPH, MDPI, vol. 17(6), pages 1-11, March.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:6:p:1978-:d:333673
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