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Lower Serum Fibroblast Growth Factor 21 Levels are Associated with Normal Lumbar Spine Bone Mineral Density in Hemodialysis Patients

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  • Yin-Ting Wu

    (School of Medicine, Tzu-Chi University, Hualien 970, Taiwan
    These authors contributed equally to this work.)

  • Bang-Gee Hsu

    (School of Medicine, Tzu-Chi University, Hualien 970, Taiwan
    Division of Nephrology, Buddhist Tzu-Chi General Hospital, Hualien 970, Taiwan
    These authors contributed equally to this work.)

  • Chih-Hsien Wang

    (School of Medicine, Tzu-Chi University, Hualien 970, Taiwan
    Division of Nephrology, Buddhist Tzu-Chi General Hospital, Hualien 970, Taiwan)

  • Yu-Li Lin

    (School of Medicine, Tzu-Chi University, Hualien 970, Taiwan
    Division of Nephrology, Buddhist Tzu-Chi General Hospital, Hualien 970, Taiwan)

  • Yu-Hsien Lai

    (Division of Nephrology, Buddhist Tzu-Chi General Hospital, Hualien 970, Taiwan)

  • Chiu-Huang Kuo

    (Division of Nephrology, Buddhist Tzu-Chi General Hospital, Hualien 970, Taiwan
    School of Post-baccalaureate Chinese Medicine, Tzu Chi University, Hualien 970, Taiwan)

Abstract

Recent evidence has indicated that fibroblast growth factor 21 (FGF21) regulates longitudinal bone growth, with increased FGF21 levels leading to bone loss. The present study evaluated the relationship between bone mineral density (BMD) and serum FGF21 levels in patients undergoing hemodialysis (HD). We analyzed blood samples from 95 patients undergoing HD and measured BMD using dual-energy X-ray absorptiometry of the lumbar vertebrae (L2–L4). Serum FGF21 concentrations were determined using a commercially available enzyme-linked immunosorbent assay kit. Thirteen (11.6%) patients were found to have osteoporosis, 27 (28.4%) osteopenia, and 57 patients had normal BMD. Advanced age and decreased body mass index, height, body weight, waist circumference, and triglyceride level were associated with lower lumbar T-scores, as were increased alkaline phosphatase, urea reduction rate, fractional clearance index for urea, and FGF21 levels. Low log-FGF21, increased body mass index, increased pre-HD body weight, and increased logarithmically transformed triglycerides (log-TG) were found to be significantly and independently associated with lumbar BMD by multivariate forward stepwise linear regression analysis with adjustment for significant confounders. We conclude that high serum FGF21 level is negatively associated with BMD in patients undergoing HD.

Suggested Citation

  • Yin-Ting Wu & Bang-Gee Hsu & Chih-Hsien Wang & Yu-Li Lin & Yu-Hsien Lai & Chiu-Huang Kuo, 2020. "Lower Serum Fibroblast Growth Factor 21 Levels are Associated with Normal Lumbar Spine Bone Mineral Density in Hemodialysis Patients," IJERPH, MDPI, vol. 17(6), pages 1-8, March.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:6:p:1938-:d:333033
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    References listed on IDEAS

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    1. Andrea Palermo & Dario Tuccinardi & Giuseppe Defeudis & Mikiko Watanabe & Luca D’Onofrio & Angelo Lauria Pantano & Nicola Napoli & Paolo Pozzilli & Silvia Manfrini, 2016. "BMI and BMD: The Potential Interplay between Obesity and Bone Fragility," IJERPH, MDPI, vol. 13(6), pages 1-30, May.
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    Cited by:

    1. Sin-Yi Huang & Du-An Wu & Jen-Pi Tsai & Bang-Gee Hsu, 2021. "Serum Levels of Fibroblast Growth Factor 21 Are Positively Associated with Aortic Stiffness in Patients with Type 2 Diabetes Mellitus," IJERPH, MDPI, vol. 18(7), pages 1-9, March.

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