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Melatonin-Measurement Methods and the Factors Modifying the Results. A Systematic Review of the Literature

Author

Listed:
  • Beata Rzepka-Migut

    (Department of Pediatric Neurology and Pediatrics, St. Queen Jadwiga’s Regional Clinical Hospital No 2 Rzeszów, 35-301 Rzeszów, Poland)

  • Justyna Paprocka

    (Department of Pediatric Neurology, Faculty of Medical Sciences, Medical University of Silesia, 40-752 Katowice, Poland)

Abstract

Melatonin plays an important role in regulating the sleep–wake cycle and adaptation to environmental changes. Concentration measurements in bioliquids such as serum/plasma, saliva and urine are widely used to assess peripheral rhythm. The aim of the study was to compare methods and conditions of determinations carried out with the identification of factors potentially affecting the measurements obtained. We have identified a group of modifiable and unmodifiable factors that facilitate data interpretation. Knowledge of modifiers allows you to carefully plan the test protocol and then compare the results. There is no one universal sampling standard, because the choice of method and biofluid depends on the purpose of the study and the research group.

Suggested Citation

  • Beata Rzepka-Migut & Justyna Paprocka, 2020. "Melatonin-Measurement Methods and the Factors Modifying the Results. A Systematic Review of the Literature," IJERPH, MDPI, vol. 17(6), pages 1-18, March.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:6:p:1916-:d:332855
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    Cited by:

    1. Kyungsik Kim & Ho Kyung Sung & Jieun Jang & Chang-Mo Kang & Kwan Lee & Sue K. Park, 2022. "Biological Assessment of Potential Exposure to Occupational Substances in Current Semiconductor Workers with at Least 5 Years of Employment," IJERPH, MDPI, vol. 19(14), pages 1-14, July.

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