IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i6p1862-d332045.html
   My bibliography  Save this article

How Physical Activity across the Lifespan Can Reduce the Impact of Bone Ageing: A Literature Review

Author

Listed:
  • Maria Felicia Faienza

    (Department of Biomedical Sciences and Human Oncology, Paediatric Section, University of Bari “A. Moro”, 70124 Bari, Italy)

  • Giuseppe Lassandro

    (Department of Biomedical Sciences and Human Oncology, Paediatric Section, University of Bari “A. Moro”, 70124 Bari, Italy)

  • Mariangela Chiarito

    (Department of Biomedical Sciences and Human Oncology, Paediatric Section, University of Bari “A. Moro”, 70124 Bari, Italy)

  • Federica Valente

    (Section of Cardiovascular Diseases, Department of Emergency and Organ Transplantation, University of Bari, School of Medicine, 70124 Bari, Italy)

  • Loredana Ciaccia

    (Department of Biomedical Sciences and Human Oncology, Paediatric Section, University of Bari “A. Moro”, 70124 Bari, Italy)

  • Paola Giordano

    (Department of Biomedical Sciences and Human Oncology, Paediatric Section, University of Bari “A. Moro”, 70124 Bari, Italy)

Abstract

Bone remodeling is a lifelong process, due to the balanced activity of the osteoblasts (OBs), the bone-forming cells, and osteoclasts (OCs), the bone-resorbing cells. This equilibrium is mainly regulated by the WNT-ß-cathenin pathway and the RANK-RANKL/OPG system, respectively. Bone ageing is a process which normally occurs during life due to the imbalance between bone formation and bone resorption, potentially leading to osteoporosis. Bone loss associated with bone ageing is determined by oxidative stress, the result of the increasing production of reactive oxygen species (ROS). The promotion of physical exercise during growth increases the chances of accruing bone and delaying the onset of osteoporosis. Several studies demonstrate that physical exercise is associated with higher bone mineral density and lower fracture incidence, and the resulting bone mineral gain is maintained with ageing, despite a reduction of physical activity in adulthood. The benefits of exercise are widely recognized, thus physical activity is considered the best non-pharmacologic treatment for pathologies such as osteoporosis, obesity, diabetes and cardiovascular disease. We reviewed the physiological mechanisms which control bone remodeling, the effects of physical activity on bone health, and studies on the impact of exercise in reducing bone ageing.

Suggested Citation

  • Maria Felicia Faienza & Giuseppe Lassandro & Mariangela Chiarito & Federica Valente & Loredana Ciaccia & Paola Giordano, 2020. "How Physical Activity across the Lifespan Can Reduce the Impact of Bone Ageing: A Literature Review," IJERPH, MDPI, vol. 17(6), pages 1-9, March.
  • Handle: RePEc:gam:jijerp:v:17:y:2020:i:6:p:1862-:d:332045
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/6/1862/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/17/6/1862/
    Download Restriction: no
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Giuseppe Lassandro & Domenico Accettura & Paola Giordano, 2021. "Promoting Sports Practice in Persons with Hemophilia: A Survey of Clinicians’ Perspective," IJERPH, MDPI, vol. 18(22), pages 1-9, November.
    2. Denise Zdzieblik & Patrick Jendricke & Steffen Oesser & Albert Gollhofer & Daniel König, 2021. "The Influence of Specific Bioactive Collagen Peptides on Body Composition and Muscle Strength in Middle-Aged, Untrained Men: A Randomized Controlled Trial," IJERPH, MDPI, vol. 18(9), pages 1-15, April.
    3. Hyun Sook Oh, 2020. "Opposite Effects of Work-Related Physical Activity and Leisure-Time Physical Activity on the Risk of Diabetes in Korean Adults," IJERPH, MDPI, vol. 17(16), pages 1-14, August.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:6:p:1862-:d:332045. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.