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A Cohort Study of Exposure to Antihyperglycemic Therapy and Survival in Patients with Lung Cancer

Author

Listed:
  • Edvardas Danila

    (Clinic of Chest Diseases, Immunology and Allergology of Faculty of Medicine of Vilnius University, Santariskiu g. 2, Vilnius LT-08661, Lithuania
    Center of Pulmonology and Allergology of Vilnius University Hospital Santaros Klinikos, Santariškių g. 2, Vilnius LT-08661, Lithuania)

  • Donata Linkevičiūtė-Ulinskienė

    (Department of Pathology, Forensic Medicine and Pharmacology, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Čiurlionio g. 21, Vilnius LT-08661, Lithuania)

  • Rolandas Zablockis

    (Clinic of Chest Diseases, Immunology and Allergology of Faculty of Medicine of Vilnius University, Santariskiu g. 2, Vilnius LT-08661, Lithuania
    Center of Pulmonology and Allergology of Vilnius University Hospital Santaros Klinikos, Santariškių g. 2, Vilnius LT-08661, Lithuania)

  • Vygantas Gruslys

    (Clinic of Chest Diseases, Immunology and Allergology of Faculty of Medicine of Vilnius University, Santariskiu g. 2, Vilnius LT-08661, Lithuania
    Center of Pulmonology and Allergology of Vilnius University Hospital Santaros Klinikos, Santariškių g. 2, Vilnius LT-08661, Lithuania)

  • Saulius Cicėnas

    (Department of Thoracic Surgery and Oncology, National Cancer Institute, Santariškių g. 1, Vilnius LT-08660, Lithuania
    Clinic of Internal Diseases, Family Medicine and Oncology, Faculty of Medicine, Vilnius University, Santariškių g. 2, Vilnius LT-08661, Lithuania)

  • Giedrė Smailytė

    (Laboratory of Cancer Epidemiology, National Cancer Institute, P. Baublio g. 3b, Vilnius LT-08406, Lithuania
    Department of Public Health, Institute of Health Sciences, Faculty of Medicine, Vilnius University, Čiurlionio g. 21, Vilnius LT-08661, Lithuania)

Abstract

We evaluated the effect of antihyperglycemic therapy on the survival of patients with lung cancer (LC). The analysis included patients with LC and concomitant type 2 diabetes. 15,929 patients were classified into five groups: metformin users, insulin users, metformin and insulin users, sulphonylurea users and non-diabetic group. A multivariate analysis showed that exposure to either metformin or to insulin was associated with a lower risk of LC-specific mortality, and this approached statistical significance (HR 0.82, 95% CI 0.72–92 for metformin and HR 0.65, 95% CI 0.44–95 for insulin). When deaths from all causes were considered, only metformin exposure was associated with a significantly lower risk of death (HR 0.82, 95% CI 0.73–0.92). Users of sulphonylurea were at a higher risk of LC-specific and overall mortality (HRs 1.19, 95% CI 0.99–1.43 and 1.22, 95% CI 1.03–1.45). Our study shows a positive effect of metformin on the survival of patients with LC. Moreover, our results show that exposure to insulin was associated with a lower risk of LC-specific mortality, but not with deaths from all causes. The study results suggested that users of sulphonylurea may be at a higher risk of LC-specific and overall mortality.

Suggested Citation

  • Edvardas Danila & Donata Linkevičiūtė-Ulinskienė & Rolandas Zablockis & Vygantas Gruslys & Saulius Cicėnas & Giedrė Smailytė, 2020. "A Cohort Study of Exposure to Antihyperglycemic Therapy and Survival in Patients with Lung Cancer," IJERPH, MDPI, vol. 17(5), pages 1-12, March.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:5:p:1747-:d:329784
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